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[THIS PAGE SUBMITTED WITH EDGAR FILING, BUT NOT DELIVERED TO STOCKHOLDERS]                                  SCHEDULE 14A
                                 (Rule 14a-101)
                     INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION
                    Proxy Statement Pursuant to Section 14(a)
                     of the Securities Exchange Act of 1934
Filed by the  Registrant  [ X ]
Filed by a Party other than the  Registrant  [ ]
Check the appropriate box:
[X  ]    Preliminary Proxy Statement
[ ]  Confidential,  for  Use  of the  Commission  Only  (as  Permitted  by  Rule
14a-6(e)(2)) [ ] Definitive Proxy Statement [ ] Definitive  Additional Materials
[ ] Solicitation  Material  Pursuant to Rule 14a-11(c) or rule 14a-12
                           Hemispherx Biopharma, Inc.
               ---------------------------------------------------------------------------------------------------
                (Name of Registrant as Specified in its Charter)
------------------------------------------------------------------------17:
    (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)

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[ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

1)  Title of each class of securities to which transaction applies:
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3)  Per  unit  price  or other  underlying  value  of  transaction
    computed  pursuant  to  Exchange  Act Rule 0-11 (Set forth the
    amount on which the filing fee is calculated  and state how it
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[ ] Fee paid previously with preliminary materials.

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 PRELIMINARY COPY2
                           HEMISPHERX BIOPHARMA, INC.
                               1617 JFK Boulevard
                        Philadelphia, Pennsylvania 19103

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                           TO BE HELD ON SEPTEMBER 10, 2003JUNE 23, 2004

To the Stockholders of Hemispherx Biopharma, Inc.:

         You are cordially  invited to attend the Annual Meeting of Stockholders
of Hemispherx Biopharma, Inc. ("Hemispherx"), a Delaware corporation, to be held
at the Embassy Suites, 1776 Benjamin Franklin Parkway, Philadelphia Pennsylvania
19103, on Wednesday,  September 10, 2002,June 23, 2004, at 10:00 a.m. local time, for the following
purposes:

     1. To elect fivesix members to the Board of  Directors of  Hemispherx  to serve
until their respective successors are elected and qualified;

     2. To ratify the selection by HemispherxHemispherx's  audit committee of BDO Seidman,
LLP,  independent  public  accountants,  to audit the  financial  statements  of
Hemispherx for the year ending December 31, 2003; and2004;

     3. To amend  Hemispherx's  certificateapprove  the  issuance of incorporationour common  stock upon  exercise of certain
warrants and conversion of certain  debentures to increasecomply with AMEX Company Guide
Section 713;

     4. To adopt the number of authorized shares of Hemispherx's common stock.

     4.Hemispherx 2004 Equity Incentive Plan; and

     5. To transact  such other  matters as may properly come before the meeting
or any adjournment thereof.

     Only  stockholders of record at the close of business on July 14, 2003April 26, 2004 are
entitled to notice of and to vote at the meeting.

     A proxy  statement and proxy are enclosed.  If you are unable to attend the
meeting in person you are urged to sign,  date and  return  the  enclosed  proxy
promptly in the self  addressed  stamped  envelope  provided.  If you attend the
meeting in person,  you may withdraw  your proxy and vote your  shares.  We have
also enclosed our amended  annual report on Form 10-K for the fiscal year ended  December
31, 2002.2003.

                                               By Order of the Board
                                               of Directors

                                               /s/s\Ransom W. Etheridge, Secretary

Philadelphia, Pennsylvania
July, 2003May   , 2004






                                                          PRELIMINARY COPY


                                 PROXY STATEMENT


                           HEMISPHERX BIOPHARMA, INC.
                               1617 JFK Boulevard
                        Philadelphia, Pennsylvania 19103


                                  INTRODUCTION


         This proxy statement is furnished in connection  with the  solicitation
of  proxies  for  use  at the  annual  meeting  of  stockholders  of  Hemispherx
Biopharma,  Inc.  ("Hemispherx" or the "Company") to be held on Wednesday,  September 10, 2003,June
23, 2004, and at any  adjournments.  The accompanying  proxy is solicited by the
Board  of  Directors  of  Hemispherx  and is  revocable  by the  stockholder  by
notifying Hemispherx's Corporate Secretary at any time before it is voted, or by
voting in person at the annual meeting.  This proxy  statement and  accompanying
proxy will be  distributed to  stockholders  beginning on or about July 21, 2003.May 17, 2004.
The principal executive offices of Hemispherx are located at 1617 JFK Boulevard,
Philadelphia, Pennsylvania 19103, telephone (215) 988-0080.


                      OUTSTANDING SHARES AND VOTING RIGHTS

RECORD DATE; OUTSTANDING SHARES

         Only stockholders of record at the close of business on July 14, 2003,April 26, 2004,
the record  date,  are  entitled  to  receive  notice of, and vote at the annual
meeting.  As of the record date, the number and class of stock  outstanding  and
entitled to vote at the meeting was 35,757,55942,363,928 shares of common stock, par value
$.001 per  share.  Each  share of common  stock is  entitled  to one vote on all
matters.  No other class of securities  will be entitled to vote at the meeting.
There are no cumulative voting rights.

         The fivesix  nominees  receiving  the  highest  number of votes cast by the
holders of common stock represented and voting at the meeting will be elected as
Hemispherx's   directors  and  constitute  the  entire  board  of  directors  of
Hemispherx.  The  affirmative  vote  of  at  least  a  majority  of  the  shares
represented and voting at the annual meeting at which a quorum is present (which
shares voting  affirmatively also constitute at least a majority of the required
quorum) is necessary  for approval of Proposals  No. 2, 3 and 4. Pursuant to the
AMEX Company Guide, votes on Proposal No. 2. The affirmative  vote of at
least a majority of3 by Company  stockholders who own the
issueddebentures  and  outstanding  shares as of the record date is
necessary for approval ofwarrants  referred to in that  Proposal No.3. A quorum is representation in person or
by proxy at the  annual  meeting  of a  majority  of the  outstanding  shares of
Hemispherx on the record date.may not be counted with
regard to that Proposal.











REVOCABILITY OF PROXIES

         If you  attend  the  meeting,  you may vote in  person,  regardless  of
whether  you have  submitted  a  proxy.  Any  person  giving a proxy in the form
accompanying  this proxy statement has the power to revoke it at any time before
it is voted.  It may be revoked  by  filing,  with the  corporate  secretary  of
Hemispherx  at  its  principal   offices,   1617  JFK   Boulevard,   Suite  660,
Philadelphia,  PA 19103, a written notice of revocation or a duly executed proxy
bearing a later date,  or it may be revoked by attending  the meeting and voting
in person.

VOTING AND SOLICITATION

         Every  stockholder  of record is entitled,  for each share held, to one
vote on each  proposal  or item that  comes  before  the  meeting.  There are no
cumulative  voting rights.  By submitting your proxy,  you authorize  William A.
Carter and Ransom W.  Etheridge  and each of them to represent you and vote your
shares at the meeting in accordance with your instructions.  Messrs.  Carter and
Etheridge and each of them may also vote your shares to adjourn the meeting from
time to time and will be  authorized to vote your shares at any  adjournment  or
postponement of the meeting.

         Hemispherx has borne the cost of preparing, assembling and mailing this
proxy solicitation  material. The total cost estimated to be spent and the total
expenditures  to  date  for,  in  furtherance  of,  or in  connection  with  the
solicitation of stockholders is approximately $40,000.  Hemispherx may reimburse
brokerage firms and other persons  representing  beneficial owners of shares for
their expenses in forwarding soliciting materials to beneficial owners.  Proxies
may be solicited by certain of Hemispherx's  directors,  officers and employees,
without additional compensation, personally, by telephone or by facsimile.

         We have hired the firm of  MacKenzie  Partners,  Inc.  to assist in the
solicitation  of  proxies  on behalf of the Board of  Directors.  MacKenzie  has
agreed to perform this  service for a proposed fee of $5,000.00$5,000 plus  out-of-pocket
expenses.

ADJOURNED MEETING

         The chair of the meeting  may adjourn the meeting  from time to time to
reconvene  at the same or some other  time,  date and place.  Notice need not be
given of any such  adjournment  meeting if the time,  date and place thereof are
announced at the meeting at which the  adjournment is taken.  If the time,  date
and place of the adjournment  meeting are not announced at the meeting which the
adjournment is taken,  then the Secretary of the Corporation  shall give written
notice of the time, date and place of the adjournment  meeting not less than ten
(10)  days  prior  to  the  date  of  the  adjournment  meeting.  Notice  of the
adjournment  meeting also shall be given if the meeting is adjourned in a single
adjournment to a date more than 30 days or in successive  adjournments to a date
more than 120 days after the original date fixed for the meeting.

TABULATION OF VOTES

         The votes will be  tabulated  and  certified by  Hemispherx's  transfer
agent.

VOTING BY STREET NAME HOLDERS

         If you are the  beneficial  owner of shares held in "street  name" by a
broker,  the broker,  as the record  holder of the  shares,  is required to vote
those  shares  in  accordance  with  your  instructions.  If  you  do  not  give
instructions to the broker, the broker will nevertheless be entitled to vote the
shares with respect to  "discretionary"  items but will not be permitted to vote
the shares with respect to "non-discretionary"  items (in which case, the shares
will be treated as "broker non-votes").


QUORUM; ABSTENTIONS; BROKER NON-VOTES

         The  required  quorum for the  transaction  of  business  at the annual
meeting is a  majority  of the shares of common  stock  entitled  to vote at the
annual meeting, in person or by proxy. Shares that are voted "FOR," "AGAINST" or
"WITHHELD  FROM" a matter  are  treated  as being  present  at the  meeting  for
purposes of establishing a quorum and are also treated as shares represented and
voting the votes cast at the annual meeting with respect to such matter.

         While  there  is no  definitive  statutory  or case  law  authority  in
Delaware as to the proper  treatment of  abstentions,  Hemispherx  believes that
abstentions should be counted for purposes of determining both: (i) the presence
or absence  of a quorum  for the  transaction  of  business;  and (ii) the total
number of votes cast with  respect to a proposal  (other  than the  election  of
directors). In the absence of controlling precedent to the contrary,  Hemispherx
intends to treat abstentions in this manner. Accordingly,  abstentions will have
the same effect as a vote  against  the  proposal  (other  than the  election of
directors).

         Under current Delaware case law, while broker non-votes (i.e. the votes
of shares held of record by brokers as to which the underlying beneficial owners
have given no voting instructions) should be counted for purposes of determining
the  presence or absence of a quorum for the  transaction  of  business,  broker
non-votes  should not be counted for purposes of determining the number of votes
cast with respect to the  particular  proposal on which the broker has expressly
not voted.  Hemispherx intends to treat broker non-votes in this manner. Thus, a
broker  non-vote  will make a quorum  more  readily  obtainable,  but the broker
non-vote will not otherwise affect the outcome of the voting on a proposal.

DEADLINE FOR RECEIPT OF STOCKHOLDER PROPOSALS


         Proposals of  stockholders  to be considered for inclusion in the Proxy
Statement  and proxy card for the 20042005 Annual  Meeting of  Stockholders  must be
received by the Company's  Secretary,  at Hemispherx  Biopharma,  Inc., 1617 JFK
Boulevard, Philadelphia, PA 19103 no later than March 25, 2004., 2005.


         Pursuant to the Company's  Restated and Amended Bylaws all  stockholder
proposals  may be brought  before an annual  meeting of  stockholders  only upon
timely notice thereof in writing having been given the Secretary of the Company.
To be timely, a stockholder's  notice, for all stockholder  proposals other than
the nomination of candidates  for director,  shall be delivered to the Secretary
at the principal  executive  offices of the Company not less than sixty (60) nor
more than  ninety  (90) days prior to the  anniversary  date of the  immediately
preceding annual meeting of stockholders;  provided,  however, that in the event
that the annual meeting is called for a date that is not within thirty (30) days
before or after such anniversary date, the  stockholder's  notice in order to be
timely  must be so  received  not later than the close of  business on the tenth
(10th)  day  following  the day on which  such  notice of the date of the annual
meeting was mailed or public  disclosure  of the date of the annual  meeting was
made, whichever first occurs. To be timely, a stockholder's notice, with respect
to a stockholder  proposal for nomination of candidates  for director,  shall be
delivered to the Secretary at the principal executive offices of the Company not
less than ninety (90) nor more than one hundred  twenty  (120) days prior to the
anniversary  date of the immediately  preceding  annual meeting of stockholders;
provided,  however,  that in the event that the  annual  meeting is called for a
date that is not within thirty (30) days before or after such anniversary  date,
the  stockholder's  notice in order to be timely must be so  received  not later
than the close of business on the tenth  (10th) day  following  the day on which
such notice of the date of the annual meeting was mailed or public disclosure of
the date of the annual  meeting  was made,  whichever  first  occurs.  Provided,
however, in the event that the stockholder proposal relates to the nomination of
candidates  for  director and the number of directors to be elected to the Board
of  Directors of the Company at an annual  meeting is increased  and there is no
public  announcement  by the Company  naming all of the nominees for director or
specifying  the size of the  increased  Board of  Directors at least one hundred
days prior to the first  anniversary of the preceding  year's annual meeting,  a
stockholder's  notice shall also be considered  timely, but only with respect to
nominees  for  any new  positions  created  by such  increase,  if it  shall  be
delivered to the Secretary at the principal executive offices of the Company not
later than the close of  business  on the tenth day  following  the day on which
such public announcement is first made by the Company. All stockholder proposals
must contain all of the information  required under the Company's Bylaws, a copy
of which is available upon written  request,  at no charge,  from the Secretary.
The  Company  reserves  the right to  reject,  rule out of order,  or take other
appropriate  action with respect to any proposal that does not comply with these
and other applicable requirements.





                            PROPOSALS TO STOCKHOLDERS

                                 PROPOSAL NO. 1
                              ELECTION OF DIRECTORS

         Each nominee to the board of directors will serve until the next annual
meeting of stockholders, or until his earlier resignation,  removal from office,
death or incapacity.

     Unless  otherwise  specified,  the enclosed proxy will be voted in favor of
the  election  of William A.  Carter,  Richard C.  Piani,  Ransom W.  Etheridge,
William M.  Mitchell,  Iraj-Eqhbal  Kiani,  and Iraj-Eqhbal  Kiani.Antoni  Esteve.  Information  is
furnished below with respect to all nominees.

         Set forth below is the  biographical  information  of the  nominees and
directors of Hemispherx:

     WILLIAM A. CARTER, M.D., 65,66, the co-inventor of Ampligen, joined Hemispherx
in 1978, and has served as: (a) Hemispherx's  Chief Scientific Officer since May
1989; (b) the Chairman of  Hemispherx's  Board of Directors  since January 1992;
(c)  Hemispherx's  Chief  Executive  Officer since July 1993;  (d)  Hemispherx's
President  since April,  1995; and (e) a director since 1987. From 1987 to 1988,
Dr. Carter served as Hemispherx's  Chairman.  Dr. Carter was a leading innovator
in the  development of human  interferon for a variety of treatment  indications
including  various viral diseases and cancer.  Dr. Carter received the first FDA
approval to initiate clinical trials on beta interferon product  manufactured in
the U.S. under his supervision.  From 1985 to October 1988, Dr. Carter served as
Hemispherx's  Chief Executive Officer and Chief Scientist.  He received his M.D.
degree from Duke  University  and  underwent his  post-doctoral  training at the
National  Institutes  of Health and Johns  Hopkins  University.  Dr. Carter also
served as Professor of Noeplastic  Diseases at Hahnemann Medical  University,  a
position he held from 1980 to 1998.  Dr.  Carter  served as Director of Clinical
Research  for  Hahnemann  Medical  University  Institute  for  Cancer  and Blood
Diseases,  and as a professor at Johns Hopkins  School of Medicine and the State
University of New York at Buffalo. Dr. Carter is a Board certified physician and
author of more than 200  scientific  articles,  including the editing of various
textbooks on anti-viral and immune therapy.

     RICHARD C. PIANI, 76,77, has been a director of Hemispherx since May 1995. Mr.
Piani was  employed as a principal  delegate for Industry to the City of Science
and Industry,  Paris,  France, a scientific and educational  complex,  from 1985
through 2000. Mr. Piani provided  consulting to Hemispherx in 1993, with respect
to general business strategies for Hemispherx's European operations and markets.
Mr.  Piani  served as Chairman of  Industrielle  du  Batiment-Morin,  a building
materials  corporation,  from 1986 to 1993. Previously Mr. Piani was a Professor
of International  Strategy at Paris Dauphine  University from 1984 to 1993. From
1979 to 1985, Mr. Piani served as Group Director in Charge of International  and
Commercial  Affairs for  Rhone-Poulenc and from 1973 to 1979 he was Chairman and
Chief  Executive  Officer of Societe "La  Cellophane",  the French company which
invented  cellophane and several other worldwide  products.  Mr. Piani has a Law
degree  from  Faculte de Droit,  Paris  Sorbonne  and a Business  Administration
degree from Ecole des Hautes Etudes Commerciales, Paris.

     RANSOM W.  ETHERIDGE,  64, has been a director of Hemispherx  since October
1997, and presently serves as our Secretary.secretary and general  counsel.  Mr. Etheridge
first became  associated  with  Hemispherx  in 1980 when he provided  consulting
services  to  Hemispherx  and  participated  in  negotiations  with  respect  to
Hemispherx's  initial  private  placement  through  Oppenheimer  & Co., Inc. Mr.
Etheridge has been practicing law since 1967, specializing in transactional law.
Mr.  Etheridge is a member of the Virginia State Bar, a Judicial  Remedies Award
Scholar and has served as President of the Tidewater Arthritis Foundation. He is
a graduate of Duke University the Wharton School Business Real Estate  Investment  Analysis
Seminar, and the University of Richmond School of Law.

     WILLIAM M.  MITCHELL,  M.D.,  68,69, has been a director  since July 1998. Mr.Dr.
Mitchell  is a  Professor  of  Pathology  at  Vanderbilt  University  School  of
Medicine.  Dr.  Mitchell  earned an M.D. from  Vanderbilt and a Ph.D. from Johns
Hopkins University,  where he served as an Intern in Internal Medicine, followed
by a Fellowship at its School of Medicine.  Dr.  Mitchell has published over 200
papers,  reviews and abstracts  dealing with viruses and anti-viral  drugs.  Dr.
Mitchell  has worked for and with many  professional  societies,  including  the
International  Society for Interferon Research,  and committees,  among them the
National  Institutes of Health,  AIDS and Related  Research  Review  Group.  Dr.
Mitchell previously served as a director of Hemispherx from 1987 to 1989.

     IRAJ-EQHBAL  KIANI,  M.B.A.,PH.D.,  58,  was  appointed  to the  Board of
Directors  on May 1, 2002.  Dr.  Kiani is a citizen of  England  and  resides in
Newport,  California.  As a native of Iran,  Dr. Kiani  served in various  local
government  positions  including the Governor of Yasoi,  Capital of  Boyerahmad,
Iran.  In 1980,  Dr. Kiani moved to England,  where he  established  and managed
several  trading  companies  over a  period  of some 20  years.  Dr.  Kiani is a
planning  and  logistic  specialist  who  is  now  applying  his  knowledge  and
experience to build a worldwide  immunology network which will use the Company's
proprietary technology.  Dr. Kiani received his Ph.D. degree from the University
of Warwick in England.

     ANTONI  ESTEVE,  Ph.D.,  45,  became a member of our Board of  Directors in
November 2003. Dr. Esteve is a Member of the Executive Committee and Director of
Scientific and Commercial Operations for Laboratorios del Dr. Esteve S.A. He has
been  engaged  at  Laboratorios  del Dr.  Esteve  since  1984.  Since 1986 he is
Professor at the Autonomous University of Barcelona, School of Pharmacy. In 2001
he was elected as member of the Advisory  Board for R&D of the Spanish  Ministry
of Science and  Technology.  Since 2002 he also has been  President of Centre de
Transfussio  i Banc de Teixits  (the  Transfusion  and  Tissues  Bank  Center of
Catalonia).  Dr.  Esteve  received a degree in Pharmacy  from the  University of
Barcelona, Faculty of Pharmacy, in 1981 and a Ph.D. in Pharmaceutical Science in
1990.

     THE BOARD OF DIRECTORS  DEEMS PROPOSAL NO. 1 TO BE IN THE BEST INTERESTS OF
HEMISPHERx  AND ITS  STOCKHOLDERS  AND  RECOMMENDS  A VOTE  "FOR" ALL FIVESIX OF THE
ABOVE-NAMED NOMINEE DIRECTORS OF HEMISPHERx'.HEMISPHERX.









                      INFORMATION CONCERNING BOARD MEETINGS

         Hemispherx  board  of  directors  met four  times  and  executed  fourthree
Unanimous  Consents,  the  Compensation  Committee  met  once,two  times,  the  Audit
Committee  met fivefour times,  and the Strategic  Planning  Committee met oncetwo times
during the fiscal year ended December 31, 2002.2003. Four of the incumbent  directors
attended  100% of the Board  Meetings  and one  incumbent,  Iraj  Eqhbal  Kiani,
attended two meetings.

                 INFORMATION CONCERNING COMMITTEES OF THE BOARD

         The board of directors maintains the following committees:

Executive Committee.

         The  Executive  Committee  is  composed  of  William A.  Carter,  Chief
Executive  Officer and President,  Ransom W. Etheridge,  Secretary and director,
and  Iraj-Eqhbal  Kiani.  The  Executive  Committee  makes   recommendations  to
management regarding general business matters of Hemispherx.

Compensation Committee.

         The  Compensation  Committee  is  composed  of  Ransom W. Etheridge,  Secretary
andDr.  William  Mitchell,
director,  and Richard C. Piani,  director.  The  Compensation  Committee  makes
recommendations  concerning  salaries  and  compensation  for  employees  of and
consultants to Hemispherx.

Nominating Committee.

         The  Nominating  Committee  is composed of Dr.  William  Mitchell,  Dr.
Iraj-Eqhbal Kiani and Richard Piani, all determined by the Board of Directors to
be  independent  directors  under the AMEX  Company  Guide.  This  Committee  is
responsible for  recommending to the Board the slate of nominees to be put forth
for election by the  stockholders  at our annual  meeting.  This  Committee also
reviews  proposals  for  nominations  from  stockholders  that are  submitted in
accordance with the procedures published in our proxy statement.

         The  Nominating  Committee  does  not  currently  have a  charter.  The
committee utilizes a subjective  analysis to identify and evaluate candidates to
be  nominated  as  directors,  including  but not limited to,  general  business
knowledge,  experience  with  financial  reporting,  interest  in the  Company's
business and related marketing  businesses,  and willingness to serve.  However,
there are  currently no minimum  qualifications  or  standards  that the Company
seeks for director nominees.  The Company does not engage or pay any third party
to assist in the process of identifying or evaluating  candidates for a director
position.   The  Company  would  consider   candidates  for  director   nominees
recommended by stockholders in accordance with the requirements of Delaware law.
If stockholder  nominations were made, the Nominating Committee would perform an
investigation  of the candidate to determine if the candidate were qualified and
would present the stockholder nomination in the proxy statement to be subject to
a vote of the stockholders.

Audit Committee.

     OurCommittee and Audit Committee Expert.

     Hemispherx's  Audit Committee of the Board of Directors consists of Richard
Piani, Committee Chairman, William Mitchell, M.D. and Iraj-Eqhbal Kiani.Iraj Eqhbal Kiani, M.B.A.,
Ph.D. Mr. Piani, Dr. Mitchell and Dr.  Iraj-Eqhbal  Kiani, are  Independent  Directors.  We doall determined by the
Board of Directors to be independent  directors under Section  121B(2)(a)(i)  of
the AMEX Company Guide.  Hemispherx does not have a financial  expert as defined
in Securities and Exchange  Commission  rules on the committee in the true sense
of the  description.  However,  Mr. Piani is a  Businessmanbusinessman  and has 40 years of
experience  of working with budgets, analyzing financials and dealing with financial
institutions.  The CompanyHemispherx believes Mr. Piani, Dr. Mitchell and Iraj-EqhbalIraj Eqhbal Kiani
to be  independent  of  management  and  free  of any  relationship  that  would
interfere  with  their  exercise  of  independent  judgementjudgment  as  members of this
committee.  The principal  functions of the Audit  Committee are to serve(i) annually
recommend independent accountants, (ii) prepare the reports or statements as may
be  required  by AMEX or the  securities  laws,  (iii)  review the  adequacy  of
Hemispherx's  system of internal  accounting  controls and Hemispherx's  audited
financial  statements and reports,  (iv) discuss the statements and reports with
management,  including any  significant  adjustments,  management  judgments and
estimates,  new accounting policies and disagreements with management,  and (vi)
review  disclosures by independent  accountants  concerning  relationships  with
Hemispherx and the performance of Hemispherx's independent accountants.

         The Board of Directors is currently  reviewing the charter of the Audit
Committee  and plan to vote on an  independentupdated  and  objective partyrevised  charter  at the  Board
Meeting scheduled for June 23, 2004.

Audit Committee Report.

         The primary  responsibility of the Audit Committee (the "Committee") is
to assist the Board of Directors in monitoringdischarging  its oversight  responsibilities
with respect to financial matters and compliance with laws and regulations.  The
primary methods used by the Committee to fulfill its responsibility with respect
to financial matters are:

     o To  appoint,  evaluate,  and,  as the  Committee  may  deem  appropriate,
terminate and replace our independent auditors;

     o To monitor the independence of our independent auditors;

     o To determine the compensation of our independent auditors;

     o To pre-approve any audit services,  and any non-audit  services permitted
under applicable law, to be performed by our independent auditors;

     o To review our risk exposures, the adequacy of related controls and
              policies with respect to risk assessment and risk management;

     o To monitor the integrity of theour financial statementsreporting processes and systems
of the
Company,  thecontrol  regarding  finance,  accounting,  legal  compliance by the Company with legal and  regulatory  requirements,information
systems;

     o To  facilitate  and  the independence and performancemaintain an open avenue of  the Company's auditors.

Audit Committee Report.

         The Audit  Committee  ofcommunication  among the
Board of Directors, wasmanagement and our independent auditors.

         The Audit Committee is composed of three  independent  directors,  and operates under a written charter prepared and adopted
by the Board has
determined  that each of Directors.  Onethose  directors is independent as that term is defined
in Sections 121(B)(2)(a)(i) of these members,  Ransom Etheridge, as a result
of his increased activity with the American Stock Exchange Company no longer deemed  independent.  TheGuide.

     In March 2004, the Board re-elected Mr. Piani, Dr. Mitchell and Iraj-Eqhbal
Kiani to the Audit Committee recommendseffective March 11, 2004, subject to their election
to the Board by stockholders at the Annual Meeting.

         The Committee has met four times in 2003.

         In  discharging  its  responsibilities  relating to internal  controls,
accounting  and  financial  reporting  policies  and  auditing  practices,   the
Committee discussed with our independent auditor, BDO Seidman,  LLP, the overall
scope and process for its audit. The Committee regularly meets with BDO Seidman,
LLP,  with and  without  management  present,  to  discuss  the  results  of Directors,  subject  to  stockholders'
ratification,its
examinations,  the selectionevaluations of the Company's independent accountants.

         Management  is  responsible  for the  Company'sour internal  controls and the overall quality
of our financial reporting process.reporting.

         The Company's independent accountants, BDO Seidman,
LLP  ("BDO"),  are  responsible  for  performing  an  independent  audit  of the
Company's   consolidated   financial  statements  in  accordance  with  auditing
standards generally accepted in the United States of America, and for expressing
an  opinion  on  the  conformity  of  the  financial  statements  to  accounting
principles  generally accepted in the United States of America.  The Committee's
responsibility,  as the representative of the Board of Directors,  is to monitor
and oversee the processes.

         In this context, the Committee met and held discussions with management
and BDO.  Management  represented  to the Committee  that the Company's  audited
financial  statements  were prepared in accordance  with  accounting  principles
generally  accepted  with the United  States of America,  and the  Committee has
reviewed and discussed the audited financial statements with management and BDO.
In addition,  the Committee has discussed with BDO Seidman,  LLP its judgments  about
the mattersquality, in addition to the acceptability,  of our accounting  principles as
applied in our  financial  reporting,  as  required to be
discussed  by  Statement  on  Auditing
Standards No. 61 Communication"Communications with Audit Committees."

         The Audit Committee also has received the written  disclosures and the letter
from BDO Seidman, LLP that is required by Independence  Standards Board Standard
No. 1, Independence  Discussions with Audit  Committees,  and has discussed with
BDO its
independence fromSeidman, LLP their independence.

         The  Committee  has met  and  held  discussions  with  management.  The
Committee  has reviewed  and  discussed  with  management  Hemispherx's  audited
consolidated  financial  statements as of and for the Company.fiscal year ended December
31, 2002 and the audited  consolidated  financial  statements  as of and for the
fiscal year ended December 31, 2003.

         Based on the reviews discussions  and other  mattersdiscussions  referred to in the
preceding  paragraph,above,  the Committee
recommended  to the Board of  Directors  that the audited  consolidated  financial  statements
referred to above be included in the  Company'sour  Informational  Statement and Annual Report
Form on Form 10-K for the fiscal year ended December 31, 2002.2003.

         This  report is  respectfully  submitted  by the  members  of the Audit
Committee of the Company's Board of Directors.


                           Richard C. Piani, Chairman
                               William M. Mitchell
                                Iraj-Eqhbal Kiani

Code of Ethics.

OurEthics

Hemispherx's  Board of Directors  adopted a code of ethics and business  conduct
for officers,  directors  and  employees  that went into effect on May 19, 2003.
This  code has  been  presented  and  reviewed  by each  officer,  director  and
employee.  You may  obtain  a copy of this  code  by  visiting  our web  site at
www.hemispherx.net  or by written  request to our office at 1617 JFK  Boulevard,
Suite 660, Philadelphia, PA 19103. Our board of directors is required to approve
any  waivers  of the code of  ethics  and  business  conduct  for  directors  or
executive  officers and we are  required to disclosed  any such waiver in a Form
8-K within five days.

Strategic Planning Committee.

         The Strategic  Planning  Committee is composed of William A. Carter and
Richard C. Piani. The Strategic Planning Committee makes  recommendations to the
board of directors of priorities in the  application of  Hemispherx's  financial
assets  and  human   resources  in  the  fields  of  research,   marketing   and
manufacturing.  The Strategic Planning Committee has engaged a number of leading
consultants in healthcare, drug development and pharmaeconomics to assist in the
analysis of various products being developed and/or potential acquisitions being
considered by Hemispherx.


Communication with the Board of Directors

         Interested  parties  wishing to contact the board of  directors  of the
Company may do so by writing to the following address:  Board of Directors,  c/o
Ransom  Etheridge,  Director,  Corporate  Secretary  and General  Counsel,  2610
Potters Rd.,  Virginia Beach, VA 23452. All letters received will be categorized
and  processed by the Corporate  Secretary  and then  forwarded to the Company's
Board or Directors.


Director Attendance at Annual Meetings of Shareholders

         Directors  are  encouraged,  but not  required,  to attend  the  Annual
Meeting of  Stockholders.  At the 2003 Annual Meeting,  four of the five sitting
directors were in attendance.

                    INFORMATION CONCERNING EXECUTIVE OFFICERS

         The following sets forth  biographical  information about  Hemispherx's
executive officers and key personnel:

         Name                     Age    Position
        -----------------------   ----   --------------------------------------
         William A. Carter, M.D.   6566    Chairman, Chief Executive Officer, and
                                         President
         Robert E. Peterson        6667    Chief Financial Officer

         David R. Strayer, M.D.    5758    Medical Affairs,Director, Regulatory Affairs

         Mei-June Liao, Ph.D.      53    Vice President of Regulatory Affairs,
                                         Quality Control and
                                         Research and Development
         Robert Hansen             60    Vice President of Manufacturing

         Carol A. Smith, Ph.D.     5154    Director of Manufacturing
                                                   and Process Development

         Ransom W. Etheridge       64    Secretary/TreasurerSecretary and General Counsel


     For  biographical  information  about  William A.  Carter,  M.D. and Ransom
Etheridge,  please see the discussion under the heading "Proposal No. 1 Election
of Directors" above.

     ROBERT E.  PETERSON  has served as Chief  Financial  Officer of the Company
since April 1993 and served as an Independent  Financial  Advisor to the Company
from 1989 to April 1993.  Also, Mr. Peterson has served as Vice President of the
Omni Group,  Inc., a business  consulting  group based in Tulsa,  Oklahoma since
1985.  From 1971 to 1984, Mr.  Peterson  worked for PepsiCo,  Inc. and served in
various  financial  management  positions  including  Vice  President  and Chief
Financial  Officer of PepsiCo Foods  International  and PepsiCo  Transportation,
Inc. Mr. Peterson is a graduate of Eastern New Mexico University.

     DAVID R.  STRAYER,  M.D. who served as Professor of Medicine at the Medical
College of  Pennsylvania  and  Hahnemann  University,  has acted as the  Medical
Director of the Company  since 1986. He is Board  Certified in Medical  Oncology
and Internal Medicine with research interests in the fields of cancer and immune
system  disorders.  Dr. Strayer has served as principal  investigator in studies
funded by the Leukemia Society of America,  the American Cancer Society, and the
National  Institutes of Health.  Dr. Strayer  attended the School of Medicine at
the University of California at Los Angeles where he received his M.D. in 1972.

     MEI-JUNE LIAO,  Ph.D.  has served as Vice President of Regulatory  Affairs,
Quality and Research & Development  since October 2003 and as Vice  President of
Research  &  Development  since  March  2003  with   responsibilities   for  the
regulatory,  quality control and product  development of Alferon(R).  Before the
acquisition  of certain  assets of ISI, Dr. Liao was Vice  President of Research
and Development  from 1995 to 2003 and held senior positions in the Research and
Development  Department  of ISI from 1983 to 1994.  Dr. Liao  received her Ph.D.
from Yale University in 1980 and completed a three year postdoctoral appointment
at the  Massachusetts  Institute  of  Technology  under the  direction  of Nobel
Laureate in Medicine,  Professor H. Gobind  Khorana.  Dr. Liao has authored many
scientific publications and invention disclosures.

ROBERT HANSEN joined the Company as Vice President of Manufacturing in 2003 upon
the  acquisition of certain assets of ISI. He is responsible for the manufacture
of Alferon N(R).  Mr. Hansen had been Vice  President of  Manufacturing  for ISI
since 1997, and served in various capacities in manufacturing  since joining ISI
in 1987. He has a B.S. degree in Chemical  Engineering from Columbia  University
in 1966.

     CAROL A. SMITH, Ph.D. has served as the Company's Director of Manufacturing
and Process  Development  since April 1995, as Director of Operations since 1993
and as the Manager of Quality Control from 1991 to 1993, with responsibility for
the   manufacture,   control  and  chemistry  of  Ampligen(R).   Dr.  Smith  was
Scientist/Quality  Assurance Officer for Virotech International,  Inc. from 1989
to 1991 and Director of the Reverse  Transcriptase  and Interferon  Laboratories
and a Clinical  Monitor for Life Sciences,  Inc. from 1983 to 1989. She received
her Ph.D.  from the University of South Florida  College of Medicine in 1980 and
was an NIH post-doctoral  fellow at the Pennsylvania State University College of
Medicine.

                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

         We have employment  agreements  with certain of our executive  officers
and have  granted  stock  options and  warrants to purchase  common stock to our
officers and  directors.  These  employment  agreements and grants are discussed
under the headings  "Compensation  of  Executive  Officers  and  Directors"  and
"Security Ownership of Certain Beneficial Owners and Management" below.

         Ransom W.  Etheridge,  a  Directoran officer and  director of the  Company,  is an
attorney in private  practice who has rendered  corporate  legal  services to us
from time to time,  for  which he has  received  fees.  Mr.  Etheridge  received
$60,000 for his professional services in 2003.

         Richard C. Piani, a Directordirector of the Company, lives in Paris, France and
assists  the  Company's  European  subsidiary  in their  dealings  with  medical
institutions and the European Medical Evaluation Authority. William M. Mitchell,
M.D.,  a Directoranother director of the Company,  works with David R. Strayer,  M.D. (our(the
Company's Medical Director) in establishing  clinical trial protocols as well as
other  scientific  work for the Company from time to time.  For these  services,
these Directorstwo directors were paid an aggregate of $170,150$40,100 in the year 2002. No individual Director was paid in excess of $60,000.2003.  William
A. Carter,  Chief  Executive  Officer of the  Company,  received an aggregate of
$12,486$12,106 in short term  advances  in 2002 which were  repaid as of  December  31,
2002.  All advances  bear  interest at 6% per annum.  The Company  loaned  $60,000 to Ransom W.Mr.  Etheridge  a Director of the Company  in November  20022001 for the
purpose  of  exercising  15,000  Class A  Redeemable  warrants.  This loan bears
interest at 6% per annum.  Dr. Carter's short term advances and Mr.  Etheridge's
loan were approved by the Board of Directors.

         WeThe Company  paid  $57,750,  $33,450  and $18,800 for the years  ending
December 31, 2001, 2002 and 2003, respectively, to Carter Realty for the rentalrent of
property used by us for
business  purposes at various times in 2002.2001,  2002 and 2003. The property is owned by
others and managed by Carter  Realty.  Carter Realty is owned by Robert  Carter,
the brother of William A. Carter.Carter, the Company's Chief Executive Officer.

     Antoni Esteve, one of the Company's directors, is a member of the Executive
Committee and Director of Scientific and Commercial  Operations of  Laboratorios
Del Dr. Esteve S.A. In March 2002, the Company's European subsidiary  Hemispherx
S.A. entered into a Sales and Distribution  Agreement with  Laboratorios Del Dr.
Esteve S.A. In addition, in March 2003, we issued 347,445 shares of common stock
to Provesan S.A., an affiliate of Laboratorios  Del Dr. Esteve S.A., in exchange
for 1,000,000 Euros of convertible  preferred equity  certificates of Hemispherx
S.A., owned by Laboratorios Del Dr. Esteve S.A.

         There are no material  proceedings  to which any  officer,  director or
affiliate,  or any associate  thereof is a party adverse to the Company or has a
material interest adverse to the Company.

                COMPLIANCE WITH SECTION 16(a) OF THE EXCHANGE ACT

         Section  16(a) of the Exchange Act requires  Hemispherx's  officers and
directors,  and persons who own more than ten percent of a  registered  class of
Hemispherx's equity securities, to file reports with the Securities and Exchange
Commission  reflecting their initial position of ownership on Form 3 and changes
in ownership on Form 4 or Form 5.

         Based  solely  on a review  of the  copies of such  forms  received  by
Hemispherx,  Hemispherx believes that, during the fiscal year ended December 31,
2002,2003,  its officers,  directors and ten percent  stockholders  complied with all
applicable Section 16(a) filing  requirements on a timely basis.basis, except that Dr.
Carter,  Dr.  Mitchell  and Mr.  Piani  each  filed a Form 5 late in which  each
reported one transaction that should have been reported on a Form 4 during 2003;
Mr.  Etheridge  filed a Form 5 late in which he reported two  transactions  that
should have been reported on a Form 4 during 2003; and Dr. Esteve and Mr. Kiani,
we have been informed, are each in the process of filing a Form 3.

                COMPENSATION OF EXECUTIVE OFFICERS AND DIRECRTORSDIRECTORS

         The  summary   compensation   table  below  sets  forth  the  aggregate
compensation  paid or accrued by Hemispherx  for the fiscal years ended December
31, 2003, 2002 and 2001 and 2000 to (I)(i) the Chief Executive Officer and (ii) Hemispherx's
four most highly paid  executiveexecutives  who were serving as  executives at the end of
the last completed  fiscal year and whose total annual salary and bonus exceeded
$100,000 (collectively, the "Named Executives").


                             
SUMMARY COMPENSATION TABLE Name and Principal Position Year Salary ($) Restricted Stock Warrants & All Other Awards Option Awards Compensation (1) - ------------------------------------------ -------- ---------------- ------------------ ------------------ ----------------- William A. Carter 2002 (5)$468,830 - (2)1,000,000 $25,747 Chairman of the Board and CEO 2001 (5)456,608 - (3) 386,650 22,917 2000 (5)539,620 - (6) 100,000 22,917 Robert E. Peterson 2002 $151,055 - (2) 200,000 - Chief Financial Officer 2001 146,880 - (4) 40,000 - 2000 145,944 - - - David R. Strayer, M.D. 2002 $178,594 - (2) 50,000 - Medical Director 2001 174,591 - (7) 10,000 - 2000 (7) 172,317 - - - Carol A. Smith, Ph.D. 2002 $128,346 - (4) 20,000 - Director of Manufacturing 2001 124,800 - - - 2000 124,000EXECUTIVE COMPENSATION SUMMARY COMPENSATION TABLE Name and Principal Year Salary ($) Restricted Warrants All Other Position Stock Awards & Options Compensation Awards (1) - --------------------- -------- ------------ ------- ------------ ----------- William A. Carter 2003 (4)$582,461 - (5)1,450,000 $37,175 Chairman of the Board 2002 (4) 565,514 - (8)1,000,000 25,747 and CEO 2001 (4) 551,560 - (2) 386,650 22,917 Robert E. Peterson 2003 (9)$230,450 - - - Chief Financial Officer 2002 151,055 - (8) 200,000 - 2001 146,880 - (3) 40,000 - 2003 David R. Strayer, M.D. 2003 (6)$190,096 - (8) 50,000 - Medical Director 2002 (6) 178,594 - (7) 10,000 -
2001 (6) 174,591 - Carol A. Smith, Ph.D. 2003 $140,576 - - - Director of 2002 128,346 - (8) 20,000 - Manufacturing 2001 124,800 - (7) 10,000 - Robert Hansen, V.P. of 2003 (10)$104,500 - - - Manufacturing 2002 - - - - 2001 - - - - (1) Consists of insurance premiums paid by Hemispherxus with respect to term life and disability insurance for the benefit of the named executive officer. (2) Represents warrants to purchase shares of our common stock at $2.00 per share. (3) Consists of 188,325 warrants to purchase common stock at $6.00 per share and 188,325 warrants to purchase common stock at $9.00 per share. Also includes a stock option grant of 10,000 shares exercisable at $4.03 per share. (4) Consists(3) Consist of a stock option grant of 10,000 shares exercisable at $4.03 per share and 30,000 warrants to purchase common stock at $5.00 per share. (5)(4) Includes a bonusbonuses of $90,397 paid$94,952, $96,684 and $99,481 in 2000.2001, 2002 and 2003, respectively. Also includes funds previously paid to Dr. Carter by Hahnemann Medical University where he served as a professor until 1998. This compensation was continued by the Companyus and totaled $79,826 in each of 2000, and 2001, and $82,095 in 2002. (6)2002 and $84,776 in 2003. (5) Represents warrants to purchase common stock exercisable at $6.25$2.20 per share. (7) Consists of a stock option grant of 10,000 shares exercisable at $4.03 per share. (8)(6) Includes $98,926 paid by Hahnemann Medical University where Dr. Strayer served as a professor until 1998. This compensation was continued by the Companyus in 2000, 2001, 2002 and 2002. (9) Consists2003. (7) Consist of stock option grant of 10,000 shares exercisable at $4.03 per share.
The following table sets forth certain information regarding the stock options and warrants granted during 2002 to the executive officers named in the above Summary Compensation Table. ============================================================================== ======================== =========================(8) Represents number of warrants to purchase shares of common stock at $2 per share. (9) 2003 includes a bonus of $74,464 paid in 2004. (10) Compensation since March 2003. Employed by ISI prior to that. The following table sets forth certain information regarding stock warrants granted during 2003 to the executive officers named in the Summary Compensation Table. INDIVIDUAL GRANTS - ------ ---------------------------- -------- ---------- ------------------- - ------ ------------ --------------- -------- ---------- ------------------- NAME NUMBER OF PERCENTAGE OF EXERCISE EXPIRATION POTENTIAL REALIZABLE TOTAL WARRANTS DATE VALUE AT ASSUMED SECURITIES GRANTED TO RATES OF UNDERLYING EMPLOYEES IN STOCK PRICE WARRANTS FISCAL YEAR PRICE PER APPRECIATION FOR OPTION AND WARRANTS TERM - ----------------- ------------------------------ ----------------------------- ------------- ----------- ------------ ------------ PERCENTAGE OF TOTAL OPTIONS EXERCISE NAME NUMBER OF SECURITIES AND WARRANTS GRANTED TO PRICE EXPIRATION UNDERLYING OPTIONS AND EXPLOYEES IN FISCAL YEAR PER SHARE(3) DATE WARRANTS GRANTED (1) 2001(2) AT 5% (4) AT 10% (4) - ----------------- ------------------------------ ----------------------------- ------------- ----------- ------------ ------------- Carter, W.A. 1,000,000 61.6% $2.00 8/13/07 $1,879,500 $ 1,969,000 - ----------------- ------------------------------ ----------------------------- ------------- ----------- ------------ ------------- Peterson, R. 200,000 12.3% $2.00 8/13/07 $375,900 $393,800 - ----------------- ------------------------------ ----------------------------- ------------- ----------- ------------ ------------- Smith, C. 20,000 1.2% $2.00 8/13/07 $37,590 $39,380 - ----------------- ------------------------------ ----------------------------- ------------- ----------- ------------ ------------- Strayer, D. 50,000 3.1% $2.00 8/13/07 $93,975 $98,450 ================ ============================== ============================= ============= =========== ============ ============= * Amounts indicate warrants granted.
(1) Options vest over a three-year period. Warrants vest immediately.2002(2) SHARE (3) FOR WARRANTS TERM - ------ ----------- -------------- --------- ---------- ------------------ - ------ ----------- -------------- --------- ---------- --------- --------- 5% (4) 10%(4) - ------ ----------- -------------- --------- ---------- --------- --------- - ------ ----------- -------------- --------- ---------- --------- --------- Carter, W.A.1,450,000 100% $2.20 9/8/08 $4,071,338 $5,137,527 - ------ ----------- -------------- --------- ---------- --------- --------- (1) These warrants became exercisable on March 17, 2004, when the second ISI acquisition was completed. (2) Total warrants issued to employees in 20022003 were 1,622,000.1,450,000. (3) The exercise price is equal to the closing price of the Company's common stock at the date of issuance. (4) Potential realizable value is based on an assumption that the market price of the common stock appreciates at the stated rates compounded annually, from the date of grant until the end of the respective option term. These values are calculated based on requirements promulgated by the Securities and Exchange Commission and do not reflect the Company'sour estimate of future stock price appreciation.
AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR AND FISCAL YEAR-END OPTION VALUE Shares Securities Underlying Value of Unexercised Acquired on Value Unexercised Option In-the-Money Options Name Exercise Realized at Fiscal Year End (#) at Fiscal Year End ($) (1) - --------------------------------------------------------------------------------------------------------- (#) ($) Exercisable Unexercisable Exercisable Unexercisable - --------------------------------------------------------------------------------------------------------- William A. Carter - - 3,552,044 (2) 753,334 (3) $209,200 $97,500 Robert E. Peterson - - 314,240 (4) 103,334 (5) 6,300 6,300 David R. Strayer - - 101,666 (6) 28,334 (7) 3,250 3,250 Carol A. Smith - - 28,457 (8) 13,334 (9) 1,300 1,300
The following table sets forth certain information regarding the stock options held as of December 31, 2003 by the individuals named in the above Summary Compensation Table. AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR AND FISCAL YEAR-END OPTION VALUE Securities Underlying Unexercised Value of Unexercised Warrants/In-the-Money-Options At Fiscal Year Options at Fiscal Year End End (1) Numbers Dollars Name Shares Value Exercisable Unexercisable Exercisable Unexercisable Acquired Realized on ($) Exercise (#) - ------- -------- -------- ----------- ------------- ---------- ------------- - ------- -------- -------- ----------- ------------- ---------- ------------- William Carter - - 3,805,378(2) 1,950,000(3) $367,150 $217,000 Robert - - 403,750(4) - 52,000 - Peterson David Strayer - - 130,000(5) - 13,000 - Carol Smith - - 41,791(6) - 5,200 - - ---------------------------- (1) Computation based on $2.13,$2.26, the December 31, 20022003 closing bid price for the common stock on the American Stock Exchange. (2) ConsistsConsist of (i) 250,000500,000 warrants exercisable at $2.00 per share expiring on August 13, 2007 (ii) 188,325 warrants exercisable at $6.00 per share expiring on February 22, 2006 (iii) 188,325 warrants exercisable at $9.00 per share expiring on February 22, 2006 (iv) 100,000 warrants exercisable at $6.25 per share expiring on April 8, 2004 (v) 25,000 warrants exercisable at $6.50 per share expiring on September 17, 2004 (vi) 25,000 warrants to purchase common stock at $8.00 per share expiring September 17, 2004 and 6,666 stock option exercisable at $8.00 per share expiring on September 17, 2004 (vii) 10,000 stock option exercisable at $4.03 per share expiring on January 3, 2011.2011, (viii) 73,728 stock options exercisable at $2.71 per share until exercised. Also include 2,768,728includes 2,695,000 warrants and options held in the name of Carter Investments, L.C. of which W. A.W.A. Carter isin the principal beneficiary. These securities consist of (i) 340,000 warrants exercisable at $4.00 per share expiring on January 1, 2008,(ii) 170,000 warrants exercisable at $5.00 per share expiring on January 1, 2005,(iii) 300,000 warrants exercisable at $6.00 per share expiring on January 1, 2005 (iv) 20,000 warrants exercisable at $4.00 per share expiring on January 1, 2008,(v) 465,000 warrants exercisable at $1.75 expiring on June 3, 2005, (vi) 1, 400,000and 1,400,000 warrants exercisable at $3.50 per share expiring on October 16, 2004 and 73,728 stock options exercisable at $2.71 per share until exercised.2004. (3) Consists of (i) 750,000500,000 warrants exercisable at $2.00 per share expiring on August 13, 2007 and (ii) 3,334 start options1,450,000 warrants exercisable at $4.03$2.20 per share expiring on January 3, 2011.September 8, 2008. (4) Consists of (i) 6,66610,000 stock options exercisable at $4.03 per share expiring on January 3, 2011 (ii) 13,750 stock options exercisable at $3.50 per share expiring on January 22, 2007, (iii) 13,824 stock option exercisable at $4.34 per share expiring on July 17, 2003, (iv) 100,000200,000 warrants exercisable at $2.00 per share expiring on August 13, 2007, (v)(iv) 50,000 warrants exercisable at $3.50 expiring on March 1, 2006, (vi)(v) 100,000 warrants exercisable at $5.00 per share expiring on April 14, 2006 and (vii)(vi) 30,000 warrants exercisable at $5.00 per share expiring on February 28, 2009. (5) Consists of (i) 100,000 warrants exercisable at $2.00 per share expiring on August 13, 2007 and (ii) 3,334 stock options exercisable at $4.03 per share expiring on January 3, 2011. (6) Consists of (i) 25,00050,000 warrants exercisable at $2.00 per share expiring on August 13, 2007, (ii) 50,000 warrants exercisable at $4.00 per share expiring on February 28, 2008, (iii) 6,66610,000 stock options exercisable at $4.08$4.03 expiring on January 3, 2011 and (iv) 20,000 stock options exercisable at $3.50 per share expiring on January 22, 2007. (7)(6) Consists of 25,000 warrants exercisable at $2.00 per share expiring on August 13, 2007 and 3,334 stock options exercisable at $4.03 per share expiring on August 13, 2007. (8) Consists of (i) 10,000(I) 20,000 warrants exercisable at $2.00 per share expiring on August 13, 2007, (ii) 5,000 warrants exercisable at $4.00 per share expiring on June 7, 2008, (iii) 6,66610,000 stock options exercisable at $4.03 per share expiring on January 3, 2016, and (iv) 6,791 stock options exercisable at $3.50 per share expiring on January 22, 2007. (9) ConsistsNew Plan Benefits It cannot be determined at this time what benefits or amounts, if any, will be received by or allocated to any person or group of 10,000persons under the Company's 2004 Equity Incentive Plan (the " Equity Incentive Plan "), if the Equity Incentive Plan is adopted, or what amounts would have been received by any person or group of persons for the last fiscal year if the Equity Incentive Plan had been in effect. See "Proposal 4: Approval of the Hemispherx 2004 Equity Incentive Plan." The following table gives information about our Common Stock that may be issued upon the exercise of options, warrants exercisable at $2.00 per share and 3,334 stockrights under all of our equity compensation plans as of December 31, 2003. 962: Number of Securities to Weighted-average Number of securities be issued upon exercise Exercise price of Remaining available of outstanding options, exercisable at $4.03 per share expiring on January 3, 2004.Outstanding forfuture issuance warrants and rights options, warrants under equity and rights compensation plans ---------- (excluding securities reflected in column (a)) ----------- Plan Category ------------- (a) (b) (c) 977: Equity compensation plans approved by security holders: 433,134 $ 3.16 - Equity compensation plans not approved _ _ - by security holders Total 433,134 $ 3.16 - Employment Agreements Hemispherx entered into an amended and restated employment agreement with its President and Chief Executive Officer, Dr. William A. Carter, dated as of December 3, 1998, as amended in August 2003, which provided for his employment until May 8, 20042008 at an initial base annual salary of $361,586, subject to annual cost of living increases. In addition, Dr. Carter could receive an annual performance bonus of up to 25% of his base salary, at the sole discretion of the board of directors. Dr. Carter doeswill not participate in any discussions concerning the determination of his annual bonus. Dr. Carter is also entitled to an incentive bonus of 0.5% of the gross proceeds received by Hemispherxus from any joint venture or corporate partnering arrangement, up to an aggregate maximum incentive bonus of $250,000 for all such transactions. Dr. Carter's agreement also provides that he be paid a base salary and benefits through May 8, 2004 if he is terminated without "cause", as that term is defined in the agreement. This agreement was extended to May 8, 2008. Pursuant to his original agreement, as amended on August 8, 1991, Dr. Carter was granted options to purchase 73,728 shares of Hemispherx'sour common stock at an exercise price of $2.71 per share. This agreement was extended to May 8, 2008 by the Board of Directors in August, 2002. Hemispherx entered into an amended and restated employmentengagement agreement with Robert E. Peterson dated April 1, 2001, which provides for Mr. Peterson's employment as Hemispherx's Chief Financial Officer until December 31, 2003 which has been extended six months, at an annual base feesalary of $155,988 per year, subject to annual cost of living increase.increases. In addition, Mr. Peterson shall receive bonus compensation upon Federal Drug Administration approval of Ampligen based on the number of years of his employment by Hemispherxus up to the date of such approval. Mr. PetersonPeterson's agreement also received 200,000 warrantscontains a provision for severance pay equal to purchase shares of common stock with an exercise price of $2.00 in 2002.nine months compensation. Compensation of Directors DuringThe compensation package for members of the year ended December 31, 2002, each non-employee Director receivedBoard of Directors was changed on September 9, 2003. Board member compensation consists of an annual retainer of $35,000 for serving on the Board of Directors.$100,000 to be paid 50% in cash and 50% in Company common stock. In addition, each non-employee Director received $1,000 for each meeting attended. The Chairman of each committee received an additional retainer of $5,000 per year and committee members receive an additional retainer of $3,000 per year. Allcertain non-employee directors received some compensation in 20022003 for special project work performed on behalf of Hemispherx.the Company's behalf. All directors have been granted options to purchase common stock under Hemispherx'sour 1990 Stock Option Plan and\and/or Warrants to purchase common stock. HemispherxThe Company believes such compensation and payments are necessary in order for Hemispherxus to attract and retain qualified outside directors. 1993 Stock Option Plan Hemispherx's 1993 Stock Option Plan (1993 Plan), provides for the grant of options for the purchase of up to an aggregate of 138,240 shares of common stock to Hemispherx's employees, directors, consultants and others whose efforts are important to the success of Hemispherx. The 1993 Plan is administered by the Compensation Committee of the board of directors, which has complete discretion to select the eligible individuals to receive and to establish the terms of option grants. The 1993 Plan provides for the issuance of either non-qualified options or incentive stock options, provided that incentive stock options must be granted with an exercise price of not less than fair market value at the time of grant and that non-qualified stock options may not be granted with an exercise price of less than 85% of the fair market value at the time of grant. The number of shares of common stock available for grant under the 1993 Plan is subject to adjustment for changes in capitalization. This plan terminated as of July 7, 2003. No options were granted under the 1993 Plan. 1992 Stock Option Plan Hemispherx's 1992 Stock Option Plan (1992 Plan), provides for the grant of options for the purchase of up to an aggregate of 92,160 shares of common stock to Hemispherx's employees, directors, consultants and others whose efforts are important to the success of Hemispherx. The 1992 Plan is administered by the Compensation Committee of the board of directors, which has complete discretion to select the eligible individuals to receive and to establish the terms of option grants. The 1992 Plan provides for the issuance of either non-qualified options or incentive stock options, provided that incentive stock options must be granted with an exercise price of not less than fair market value at the time of grant and that non-qualified stock options may not be granted with an exercise price of less than 50% of the fair market value at the time of grant. The number of shares of common stock available for grant under the 1992 Plan is subject to adjustment for changes in capitalization. This plan expired as of December 3, 2002. No options were granted under the 1992 Plan. 1990 Stock Option Plan Hemispherx 1990 Stock Option Plan, as amended ("1990 Plan"), provides for the grant of options to employees, directors, officers, consultants and advisors of Hemispherx for the purchase of up to an aggregate of 460,798 shares of common stock. The 1990 plan is administered by the Compensation Committee of the board of directors, which has complete discretion to select eligible individuals to receive and to establish the terms of option grants. The number of shares of Commoncommon stock available for grant under the 1990 Plan is subject to adjustment for changes in capitalization. As of December 31, 2002,2003, no options to acquire an aggregate of 245,782 shares of the common stock were available for grants under the 1990 plan. This plan remains in effect until terminated by the Board of Directors or until all options are issued. 401(K) Plan In December 1995, Hemispherx established a defined contribution plan, effective January 1, 1995, entitled the Hemispherx Biopharma employees 401(K) Plan and Trust Agreement. All full time employees of Hemispherx are eligible to participate in the 401(K) plan following one year of employment. Subject to certain limitations imposed by federal tax laws, participants are eligible to contribute up to 15% of their salary (including bonuses and/or commissionscommissions) per annum. Participants' contributions to the 401(K) plan may be matched by Hemispherx at a rate determined annually by the board of directors. Each participant immediately vests in his or her deferred salary contributions, while Hemispherx contributions will vest over one year. In 20022003, Hemispherx provided matching contributions to each employee for up to 6% of annual pay for a total contribution of $38,000$34,000 for all eligible employees. Compensation Committee Interlocks and Insider Participation During the fiscal year ended December 31, 2002,2003, the members of Hemispherx's Compensation Committee were Ransom W. Etheridge and Richard Piani. Mr. Etheridge serves as the Company's Secretarysecretary and general counsel and he is an attorney in private practice and has rendered legal services to Hemispherx for which he received a fee. Mr. Piani livesreceived fees for certain consulting work performed in Paris, France and assists the Company's European subsidiary in their dealings with medical institutions and the European Medical Evaluation Authority for which he received a fee in 2001. The fees paid toEurope on Hemispherx's behalf. Mr. Etheridge and Mr. Piani in 2002 were less thanwas paid $60,000 each.for his professional services. Notwithstanding anything to the contrary, the following report of the Compensation Committee, the report of the Audit Committee on page 7,8, and the performance graph on page 2021 shall not be deemed incorporated by reference by any general statement incorporating by reference this Proxy Statement into any filing under the Securities Act of 1933, or under the Securities Exchange Act of 1934, except to the extent that the Company specifically incorporates this information by reference, and shall not otherwise be deemed filed under such Acts. Compensation Committee Report on Compensation The Compensation Committee makes recommendations concerning salaries and compensation for Hemispherx employees and consultants. The following report of the compensation committee discusses executive compensation policies and consultantthe basis of the compensation paid to Hemispherx.executive officers in 2003. In general, the Compensation Committeecompensation committee seeks to link the compensation paid to each executive officer to the experience and performance of such executive officer. Within these parameters, the executive compensation program attempts to provide an overall level of executive compensation that is competitive with companies of comparable size and with similar market and operating characteristics. The Company's policy is that executive compensation should be directly and materially related to the short-term and long-term operating performance and objectives of the Company. As such, the Compensation Committee has determined that compensation of executive officers should include a mixture of short and long range compensation elements which are intended to attract, motivate and retain competent executive personnel, increase executive ownership interests in the Company and improve operating performance of the Company. There are three elements in Hemispherx's executive compensation program, all determined by individual and corporate performance: o Base salary o Annual incentive o Long-term incentive Base Salary In establishing base salary levels for individual executives, the Compensation Committee will consider factors such as the executive's scope of responsibility, current and future potential performance, and overall competitive positioning relative to comparable positions at other companies. The objective of the Company is to structure salaries that are competitive with those of similarly situated companies. The Summary Compensation Table shows amounts earned during 20022003 by ourHemispherx executive officers. The base salary compensation for each of Dr. William A. Carter and Robert E. Petersonsuch executive officers is set by the terms of the employment engagement agreement entered into with each Executive Officer.such executive officer. Hemispherx established the base salarysalaries for its Chief Executive Officer, Dr. William A. Carter under an employment agreement datedin December 31,3, 1998 (as amended on August 14, 2002)2003), which provides for a base salary of $361,586 until May 8, 2008. Also, Hemispherx alsoentered into an extended its engagementemployment agreement with Robert E. Peterson, Chief Financial Officer which provides for a base feesalary of $155,988 until December 31, 2003.2003, which was extended six months. Dr. Carter'sCarter and Mr. Peterson's agreements provideallow for annual cost of living increases. Dr. Carter's compensation also includes funds previously paid to Dr. Carter by Hahnemann Medical University where he served as a professor until 1998. This compensation was continued by companyus and totaled $79,826 in each of 20002001, $82,095 in 2002 and 2001. In 2002, this compensation was $82,095.$84,776 in 2003. Annual IncentivesIncentive Annual incentive bonus awards are granted from time to time to executives in recognition of their contribution to the Company's business and operations, as measured against competitors of the company and the Company's internal budgets and operating plans. Under the terms of their respective agreements with the Company, ourHemispherx's Chief Executive Officer and President, Dr. William A. Carter, and our Chief Financial Officer Robert E. Peterson, may receiveare entitled to an annual incentive bonus as determined by the Compensation Committeecompensation committee based on such executive officer'sofficers' performance during the previous calendar year. The cash bonus awarded to the Company'sHemispherx's Chief Executive Officer in 19992003 and 2000 wasthe cash bonus awarded to the Chief Financial Officer in 2003 were determined based on provisions of histhis provision in their employment agreement.agreements. Long-Term Incentives The Company grants long-term incentive awards periodically to align a significant portion of the executive compensation program with stockholder interests over the long-term through encouraging and facilitating executive stock ownership. Executives are eligible to participate in the Company's incentive stock option plans. In connection with extending Dr. Carter's employment agreement in 2002, the Compensation Committee approved a grant of 1,000,000 warrants to ourHemispherx's Chief Executive Officer and President, Dr. William Carter.Carter, received a grant of 1,450,000 warrants in 2003. These warrants are exercisable at $2.00$2.20 per share. All warrantsshare and expire on August 13,September 8, 2008, unless previously exercised. Also, our Chief Financial Officer, Robert E. PetersonThese warrants vest upon consummation of the second ISI asset closing or the filing by us with the U.S. Food & Drug Administration of a new drug application, whichever happens first. The warrants vested on March 18, 2004, when the second ISI asset closing was granted 200,000 warrants to purchase common stock at $2.00 per share which expires August 13, 2008 unless previously exercised.consummated. Chief Executive Officer Compensation The Summary Compensation Table shows that during the year 20022003 the Company's Chief Executive Officer and President, Dr. William A. Carter earned $376,782$582,461 in base compensation pursuant to the terms of his employment agreement. In addition, Dr. Carter's compensation in 20022003 also includes funds previously paid by Hahnemann University where he served as a Professor until 1998. In 2002, Dr. Carter also received an aggregate of $12,486 in short term advances bearing interest at 6% per annum, of which were repaid by December 31, 2002. The Compensation Committee believes that Dr. Carter's total compensation is consistent with the median compensation for CEO's in comparable companies. Factors reviewed by the Compensation Committee's assessment of the Company's and the CEO's performance includeincludes individual performance, growth in revenue and expense management and implementation of the Company's business strategy. Compliance With Internal Revenue Code Section 162(m). One of the factors the Compensation Committee considers in connection with compensation matters is the anticipated tax treatment to Hemispherx and to the executives of the compensation arrangements. The deductibility of certain types of compensation depends upon the timing of an executive's vesting in, or exercise of, previously granted rights. Moreover, interpretation of, and changes in, the tax laws and other factors beyond the Compensation Committee's control also affect the deductibility of compensation. Accordingly, the Compensation Committee will not necessarily limit executive compensation to that deductible under Section 162(m) of the Code. The Compensation Committee will consider various alternatives to preserving the deductibility of compensation payments and benefits to the extent consistent with its other compensation objectives. This report submitted by the Compensation Committee of the Company's Board of Directors. Richard C. Piani Dr. William M. Mitchell COMPARATIVE STOCK PERFORMANCE GRAPH The following graph compares the cumulative total stockholder return for the Company's common stock since December 31, 19971998 to the cumulative total returns of (I)(i) the Standard &Poor's& Poor's Smallcap 600 Index and (ii) a peer group index for the same period, assuming an investment of $100 in each of the Company's common stock, the Standard & Poor's Smallcap 600 Index and the peer group index. [GRAPH OF TOTAL SHAREHOLDER RETURNS][GRAPHIC OMITTED][GRAPHIC OMITTED] ASSUMES $100 INVESTED ON JAN. 1, 19961998 ASSUMES DIVIDEND REINVESTED FISCAL YEAR ENDING DEC. 31, 20012003 ANNUAL RETURN PERCENTAGE Years Ending Company Name / Index Dec98 Dec99 Dec00 Dec01 Dec02 Dec03 - ------------------------------------------------------------------------------------------------------- ------ ----- ----- ----- ----- HEMISPHERX BIOPHARMA INC 69.25 44.55 -52.20 -5.26 -52.67 6.10 S&P SMALLCAP 600 INDEX -1.31 12.40 11.80 6.54 -14.63 38.79 PEER GROUP 6.85 13.61 54.46 63.31 -7.96-23.18 -33.76 48.39 -45.76 5.33 INDEXED RETURNS Base Years Ending Period Company Name / Index Dec97 Dec98 Dec99 Dec00 Dec01 Dec02 Dec03 - ------------------------------------------------------------------------------------------------------ ------ ----- ------ ----- ----- ------ HEMISPHERX BIOPHARMA INC 100 169.25 244.65 116.94 110.78 52.44144.55 69.09 65.45 30.98 32.87 S&P SMALLCAP 600 INDEX 100 98.69 110.94 124.03 132.13 112.80112.40 125.67 133.88 114.30 158.63 PEER GROUP 100 106.85 121.39 187.50 306.22 281.8576.82 50.88 75.51 40.95 43.14 Peer Group Companies - ------------------------------------------------------------------------------ GILEAD SCIENCES----------------------------------------- AVI BIOPHARMA INC ISISIMMUNE RESPONSE CORP/DE LA JOLLA PHARMACEUTICAL CO MAXIM PHARMACEUTICALS INC SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENTPRINCIPAL STOCKHOLDERS The following table sets forth as of July 10, 2003,April 26, 2004, the number and percentage of outstanding shares of common stock beneficially owned by each of our directors and the Named Executives; and all of our officers and directors as a group. As of July 10, 2003, there were no persons,by: o Each person, individually or as a group, known to Hemispherxus to be deemed the beneficial owners of five percent or more of theour issued and outstanding common stock. OFFICERS, DIRECTORS SHARES BENEFICIALLY OWNED %OF SHARE BENEFICIALLY OWNED(1) AND PRINCIPAL STOCKHOLDERS - ----------------------------------------------- -------------------------------- William A. Carter, M.D. (2) 4,202,107 (9.2%) Robert E. Peterson (3) 314,074 * Ransom W. Etheridge (4) 214,316 * Richard C. Piani (5) 196,747 * William M. Mitchell,M.D.(6) 175,640 * David R. Strayer, M.D. (7) 87,246 * Carol A. Smith (8) 28,457 * Iraj-Eqhbal Kiani (9) 12,000 * Allstock; o each of our directors and executivethe Named Executives; and o all of our officers and directors as a group (9 persons) 5,230,587 (13.3%) - ------------------------ * Less than 1% (1)group. This table is based upon information supplied by Schedules 13D and 13G, if any, filed with the Securities and Exchange Commission, and information obtained from our directors and named executives. For purposes of this table, a person or group of persons is deemed to have "beneficial ownership" of any shares of common stock which such person has the right to acquire within 60 days of July 10, 2003.days. For purposes of computing the percentage of outstanding shares of common stock held by each person or group of persons named above,in the table, any security which such person or persons has or have the right to acquire within such date is deemed to be outstanding but is not deemed to be outstanding for the purpose of computing the percentage ownership of any other person. Except as indicated in the footnotes to this table and pursuant to applicable community property laws, Hemispherx believeswe believe, based on information supplied by such persons, that the persons named in this table have sole voting and investment power with respect to all shares common stock which they beneficially own. As of April 26, 2004, 42,363,928 shares of our common stock were outstanding. Unless otherwise noted, the address of each of the principal stockholders is care of us at One Penn Center, 1617 JFK Boulevard, Philadelphia, Pennsylvania 19103. Name and Address of Shares Beneficially Owned % Of Share Beneficially Beneficial Owner Owned - ------------------------ ------------------------- --------------------- William A. Carter, M.D. 5,760,028 (1) 12.1% Robert E. Peterson 404,250 (2) * Ransom W. Etheridge 439,009(3) 1.0 2610 Potters Rd. Virginia Beach, VA 23452 Richard C. Piani 196,747(4) * 97 Rue Jeans-Jaures Levaillois-Perret France 92300 William M. Mitchell, M.D. 196,861(5) * Vanderbilt University Department of Pathology Medical Center North 21st and Garland Nashville, TN 37232 Antoni Esteve 347,446(6) * Laboratorios Del Dr. Esteve S.A. AV. Mare de Deu de Montserat Barcelona, 08041, Spain David R. Strayer, M.D. 144,746(7) * Carol A. Smith 41,791(8) * Iraj-Eqhbal Kiani 12,000(9) * Orange County Immune Institute 18800 Delaware Street Huntingdon Beach, CA 92648 Mei-June Liao, Ph.D. - - Robert Hansen - - All directors and executive officers as a group (11 persons) 7,518,185 15.4 - ------------------------ * Less than 1% (1) Includes (i) an option to purchase 73,728 shares of common stock from Hemispherx at an exercise price of $2.71 per share and expiring on August 8, 2004, (ii) Rule 701 Warrants to purchase 1,400,000 shares of common stock at a price of $3.50 per share, originally expiring on September 30, 2002 was extended to September 30, 2007;30,2007; (iii) warrants to purchase 465,000 shares of common stock at $1.75 per share issued in connection with the 1995 Standby Financing Agreement and expiring on June 30, 2005; (iv) 340,000 common stock warrants exercisable at $4.00 per share and originally expiring on January 1, 2003 was extended to January 1, 2008; (v) 170,000 common stock warrants exercisable at $5.00 per share and expiring on January 2, 2005;(vi) 25,000 warrants to purchase common stock at $6.50 per share and expiring on September 17, 2003; 2004;(vii) 25,000 warrants to purchase common stock at $8.00 per share and expiring on September 17, 2004;(viii) 100,000 warrants to purchase common stock at $6.25 per share and expiring on April 8, 2004; (ix) 20,000 warrants to purchase common stock at $4.00 per share originally expiring January 1, 2003 was extended to January 1, 2008, (x) 188,325 common stock warrants exercisable at $6.00 per share and expiring on February 22, 2006; (xi) 188,325 common stock warrants exercisable at $9.00 per share and expiring on February 22, 2006 (xii) 300,000 common stock warrants granted in 1998 that are exercisable at $6.00 per share and expiring on January 1, 2006 (xiii) options to purchase 6,66610,000 shares of common stock at $4.03 per share and expiring on January 3, 2011 (xiv) 250,000500,000 warrants exercisable $2.00 per share in August 13, 2007 (xv) 1,450,000 warrants exercisable at $2.20 per share expiring on September 9, 2008 and (x) 504,650 shares of common stock. Does not include 500,000 warrants exercisable at $2.00 per share expiring on August 13, 2007 and 650,060 shares of common stock. (3)that are not vested. (2) Includes (i) 27,57413,750 options to purchase common stock at an average exercise price of $3.92$3.50 per share, expiring on July 17, 2003January 7, 2007; (ii) warrants to purchase 50,000 shares of commonCommon stock at an exercise price of $3.50 per share, expiring on March 1, 20062006; (iii) warrants to purchase 100,000 shares of common stock at $5.00 per share, expiring on April 14, 20062006; (iv) 30,000 warrants to purchase common stock at $5.00 per share an expiring on February 28, 2009 (v) options to purchase 6,00010,000 shares at $4.03 per share that expiresexpire on January 3, 2011 (vi) 200,000 warrants exercised at $2.00 per share expiring on November 13, 2007 and (v)(vii) 500 shares of common stock. (4)(3) Includes 20,000 warrants to purchase common stock at $4.00 per share, originally expiring on January 1, 2003 and was extended to January 1, 2008; 25,000 warrants to purchase common stock at $6.50 per share; 25,000 warrants to purchase common stock at $8.00 per share, all expiring on September 12, 2004; 100,000 warrants exercisable $2.00 per share expiring on August 13, 20072007; 200,000 stock options exercisable at $2.75 per share and 44,316expiring on December 4, 2013 and 69,009 shares of common stock. (5)(4) Includes (i) 20,000 warrants to purchase 25,000 shares of common stock at $6.50$4.00 per shareshare; (ii) warrants to purchase 25,000 shares of common stock at $6.50 per shareshare; (iii) 25,000 warrants to purchase common stock at $8.00 per share, all expiring on September 17, 2004; (iv)(vi) 100,000 warrants exercisable at $2.00 per share expiring on August 13, 2007, (v)(vi) 8,847 shares of common stock owned by Mr. Piani (vi) 12,900 shares of common stock owned jointly by Mr. Andand Mrs. Piani; and (vii) 5,0005000 shares of common stock owned by Mrs. Piani. (6)(5) Includes (i)(I) warrants to purchase 12,000 shares of common stock at $6.00 per share, expiring on August 25, 2003;2008; (ii) 25,000 warrants to purchase common stock at $6.50 per share; (iii) 25,000 warrants to purchase common stock at $8.00 per share all expiring on September 17, 2004; (iv) 100,000 warrants exercisable at $2.00 per share expiring onin August 13, 2007 and 13, 64034,861 shares of common stock. (6) Consists of 347,446 shares of our common stock owned by Provesan S.A., an affiliate of Laboratorios del Dr. Esteve S.A. Dr. Antoni Esteve is a member of the executive committee and director of Scientific and Commercial Operations of Laboratorios del Dr. Esteve S.A. (7) Includes (i) stock options to purchase 20,000 shares of common stock at $3.50 per share; (ii) 50,000 warrants to purchase common stock at $4.00 per share; (iii) 2,50010,000 stock options exercisable at $4.03 per share and expiring on January 3, 20112011; 50,000 warrants to purchase common stock at $2.00 per share and expiring on August 13, 2007 and; (iv) 14,746 shares of common stock. (8) Consists of 5,000 warrants to purchase common stock at $4.00 per share expiring June 7, 2008; 6,791 stock options exercisable at $3.50 expiring January 22, 2007, 10,00020,000 warrants exercisable at $2.00 per share expiring in August 13, 2007 and options to purchase 6,66610,000 shares of common stock at $4.03$ 4.03 per share expiring on January 3, 2011. (9) Consist s of 12,000 warrants exercisable at $3.86 per share expiring on April 30, 2005. PROPOSAL NO. 2 RATIFICATION OF SELECTION OF AUDITORS The Board of Directors, upon the recommendation of the Audit Committee, has appointed the firm of BDO Seidman, LLP as independent auditors of Hemispherx for the fiscal year ending December 31, 20032004 subject to ratification by the stockholders. BDO Seidman, LLP has served as Hemispherx's independent auditors since June 2000. At the Annual Stockholder's Meeting on August 14, 2002September 10, 2003, and pursuant to the recommendation of the Audit Committee of the Board of Directors, stockholders ratified the appointment of the firm of BDO Seidman, LLP, as independent accountants, to audit the financial statements of the Company for the year end December 31, 2002.2003. All audit and professional services provided by BDO Seidman, LLP are approved by the Audit Committee. The total fees billed by BDO Seidman, LLP were $104,885 in 2001 and $178,429 in 2002.2002 and $313,992 in 2003. The fees for work in 2001 and 2002 are summarized below in terms of audit work and other work. BDO Seidman, LLP did not perform any tax work forfollowing table shows the company in 2001 or 2002. Audit Fees - The aggregate fees billed to us by BDO Seidman, LLP for professional services rendered during the year ended December 31, 2003. - -------------------- -------------------------------- Amount ($) - -------------------- -------------------------------- - -------------------- ----------------- -------------- Description of Fees 2002 2003 - --------------------- ---------------- -------------- - --------------------- ---------------- -------------- Audit Fees $173,929 $264,917 - --------------------- ---------------- -------------- - --------------------- ---------------- -------------- Audit-Related Fees 4,500 43,580 - --------------------- ---------------- -------------- - --------------------- ---------------- -------------- Tax Fees - - - --------------------- --------------- --------------- - --------------------- --------------- --------------- All Other Fees - - - --------------------- --------------- --------------- - --------------------- --------------- --------------- - --------------------- --------------- --------------- - --------------------- --------------- --------------- Total $178,429 $308,497 ======== ======== - ----------------------------------------- ----------- Audit Fees Represents fees for professional services provided for the audit of the Company'sour annual financial statements for the year ending December 31, 2001 and 2002 were approximately $96,707 in 2001 and $131,284 in 2002. These fees included review of our financial statements included in our quarterly reports and services in connection with statutory and regulatory filings. Audit-Related Fees Represents the Company's quarterly filings withfees for assurance and related services that are reasonably related to the SEC. Other Fees - The aggregate fees billed by BDO Seidman, LLP for other fees was $8,178performance of the audit or review of our financial statements, including those in 20012002 and $47,145 in 2002. These fees basically reflect BDO Seidman, LLP's work on reviewing Form S-3 registration statements and2003 related to the acquisition due diligence.of the ISI business. The Audit Committee has determined that BDO Seidman, LLP's rendering of these non-audit services is compatible with maintaining auditors independence. The Board of Directors considers BDO Seidman, LLP to be well qualified to serve as the independent public accountants of the Company. If, however, the stockholders do not ratify the appointment of BDO Seidman, LLP, the Board of Directors may, but is not required to, reconsider the appointment. It is anticipated that a representative of BDO Seidman, LLP will be present at the Annual Meeting and will be available to respond to appropriate questions. The affirmative vote of at least a majority of the shares represented and voting at the Annual Meeting at which a quorum is present (which shares voting affirmatively also constitute at least a majority of the required quorum) is necessary for approval of Proposal No. 2. Under Delaware law, there are no rights of appraisal or dissenter's rights, which arise as a result of a vote to ratify the selection of auditors. THE BOARD OF DIRECTORS DEEMS PROPOSAL NO. 2 TO BE IN THE BEST INTERESTS OF HEMISPHERX AND ITS STOCKHOLDERS AND RECOMMENDS A VOTE "FOR" APPROVAL THEREOF. PROPOSAL NO. 3 APPROVAL OF THE COMPANY'S PROPOSALISSUANCE OF 13,468,793 SHARES OF COMMON STOCK ISSUABLE UPON EXERCISE OF CERTAIN WARRANTS AND UPON CONVERSION OF CERTAIN OUTSTANDING DEBENTURES AND DEBENTURES ISSUABLE UPON EXERCISE OF CERTAIN RIGHTS TO AMEND THE ARTICLES OF INCORPORATION The BoardCOMPLY WITH AMEX COMPANY GUIDE SECTION 713 As described below, in three transactions between July 10, 2003 and January 26, 2004, we issued convertible debentures, rights to purchase convertible debentures, warrants and common stock in private transactions with accredited investors. Section 713 of Directors is proposing the American Stock Exchange ("AMEX") Company Guide provides that we must obtain stockholder approval and adoption of an amendment to the Company's Certificate of Incorporation, which increases the numberbefore issuance, at a price per share below market value, of common shares authorizedstock, or securities convertible into common stock, equal to 20% or more of our outstanding common stock. Taken separately, the three transactions do not trigger Section 713. However, the AMEX has taken the position that the three transactions should be aggregated and, as such, stockholder approval is required for issuance. The complete textexercise of all of the proposed Amendment towarrants and conversion of some of the CertificateDebentures. To assure that we are in compliance with Company Guide Section 713, we are requesting your approval of Incorporation is attached as Appendix A to this Proxy Statement. The Company's Articles currently authorize the issuance of 50,000,000 common13,468,793 shares $.001 par value, and 5,000,000 Preferred Shares, $.001 par value per share. In May, 2003, the Board(includes 2,798,097 anti-dilution shares) upon conversion of Directors adopted a resolution proposing that the Articles be amended to increase the authorized number of common shares to 100,000,000 subject to stockholder approvalall of the Amendment to the Articles. The Boardwarrants, and upon conversion of Directors has determined that adoptionall of the Amendment is in the best interestoutstanding debentures and all of the Company and unanimously recommends approval bydebentures issuable upon exercise of rights described below. Description of the stockholders. As of June 30, 2003, the Company had 35,757,559 common shares outstanding and 13,565,064 common shares reserved for future issuance under the Company's existing stock option plans and outstanding options, warrant and convertible debentures, leaving 677,377 common shares available for future grants. The Board of Directors believes that the proposed increase in authorized common shares will benefit the Company by providing flexibility to issue common shares for a variety of business and financial objectives in the future without the necessity of delaying such activities for further stockholder approval, except as may be required in particular cases by the Company's charter documents, applicable law or the rules of any stock exchange or national securities association trading system on which the Company's securities may be listed or quoted. In addition, the Company's Board of Directors could issue large blocks of Company Common Stock to fend off unwanted tender offers or hostile takeovers without further stockholder approval.transactions. - ------------------------------- On March 12,July 10, 2003, we issued an aggregate of $5,426,000 in principal amount of 6% Senior Convertible Debentures due JanuaryJuly 31, 2005 (the "July Debentures") and an aggregate of 743,288 warrants507,103 Warrants (the "July 2008 Warrants") to two accredited investors, in a private placement for aggregate grossanticipated proceeds of $4,650,000. Pursuant to the terms of the July Debentures, $1,550,000 of the proceeds from the sale of the July Debentures were to have been held back and released to us if, and only if, we acquired the facility of Interferon Sciences, Inc. ("ISI") with in a set timeframe. These funds were released to us in October 2003 although we had not acquired ISI's facility at that time. The July Debentures mature on JanuaryJuly 31, 2005 and bear interest at 6% per annum, payable quarterly in cash or, subject to satisfaction of certain conditions, common stock. PursuantAny shares of common stock issued to the terms and conditionsinvestors as payment of interest shall be valued at 95% of the Senior Convertibleaverage closing price of the common stock during the five consecutive business days ending on the third business day immediately preceding the applicable interest payment date. The July Debentures we have pledged all of our assets including the assets acquired from Interferon Sciences, Inc. other than intellectual property, as collateral and are subject to comply with certain financial and negative covenants, which include but are not limited to the repayment of principal balances upon achieving certain revenue milestone. The Debenture are convertible at the option of the investors at any time through JanuaryJuly 31, 2005 into shares of our common stock. The conversion price under the July Debentures was fixed at $2.14 per share; however, as part of the debenture placement closed on October 29, 2003 (see below), the conversion price under the July Debentures was lowered to $1.89 per share. The conversion price is subject to adjustment for anti-dilution protection for issuance of common stock or securities convertible or exchangeable into common stock at a price less than the conversion price then in effect. In addition, in the event that we do not pay the redemption price at maturity, the Debenture holders, at their option, may convert the balance due at the lower of (a) the conversion price then in effect and (b) 95% of the lowest closing sale price of our common stock during the three trading days ending on and including the conversion date. The July 2008 Warrants, as amended, received by the investors are to acquire at any time commencing on July 26, 2004 through January 31, 2009 an aggregate of 507,102 shares of common stock at a price of $2.46 per share. On July 10, 2004, the exercise price of these July 2008 Warrants will reset to the lesser of the exercise price then in effect or a price equal to the average of the daily price of the common stock between July 11, 2003 and July 9, 2004 (but in no event less than $2.14 per share). The exercise price (and the reset price) under the July 2008 Warrants also is subject to similar adjustments for anti-dilution protection. On October 29, 2003, we issued an aggregate of $4,142,357 in principal amount of 6% Senior Convertible Debentures due October 31, 2005 (the "October Debentures") and an aggregate of 410,134 Warrants (the "October 2008 Warrants") in a private placement for aggregate anticipated gross proceeds of $3,550,000. Pursuant to the terms of the October Debentures, $1,550,000 of the proceeds from the sale of the October Debentures have been held back and will be released to us if, and only if, we acquire ISI's facility within 90 days of January 26, 2004 and provide a mortgage on the facility as further security for the October Debentures. In March 2004, we acquired the facility and we are in the process of mortgaging the facility to the Debenture holders. The October Debentures mature on October 31, 2005 and bear interest at 6% per annum, payable quarterly in cash or, subject to satisfaction of certain conditions, common stock. Any shares of common stock issued to the investors as payment of interest shall be valued at 95% of the average closing price of the common stock during the five consecutive business days ending on the third business day immediately preceding the applicable interest payment date. Upon completing the sale of the October Debentures, we received $3,275,000 in net proceeds consisting of $1,725,000 from the October Debentures and $1,550,000 that had been withheld from the July Debentures. As noted above, $1,550,000 of the proceeds from the October Debentures have been held back pending our mortgaging of the ISI facility to the Debenture holders. We are in the process of providing this mortgage. The October Debentures are convertible at the option of the investors at any time through October 31, 2005 into shares of our common stock. The conversion price under the October Debentures is fixed at $1.46$2.02 per share, subject to adjustment for anti-dilution protection for issuance of common stock or securities convertible or exchangeable into common stock at a price less than the conversion price then in effect. In addition, in the event that we do not pay the redemption price at maturity, the Debenture holders, at their option, may convert the balance due at the lower of (a) the conversion price then in effect and (b) 95% of the lowest closing sale price of our common stock during the three trading days ending on and including the conversion date. The October 2008 Warrants, as amended, received by the investors also received warrantsare to acquire at any time commencing on July 26, 2004 through March 12, 2008April 30, 2009 an aggregate of 743,288410,134 shares of common stock at a price of $1.68$2.32 per share. On March 12,October 29, 2004, the exercise price of the warrantsthese October 2008 Warrants will reset to the lesser of the exercise price then in effect or a price equal to the average of the daily price of the common stock between March 13,October 29, 2003 and March 11,October 27, 2004 (but in no event less than $1.176$2.19 per share). The exercise price (and the reset price) under the warrantsOctober 2008 Warrants also is subject to similar adjustments for anti-dilution protection. AsOn January 26, 2004, we issued: (i) an aggregate of June 30, 2003, the debenture holders have converted $1,510,222$4,000,000 in principal amount of debt into 1,157,6866% Senior Convertible Debentures due January 31, 2006 (the "January 2004 Debentures"); (ii) an aggregate of 790,514 warrants (the "2009 Warrants"); (iii) 158,103 shares of common stock; and (iv) Additional Investment Rights ("AIR") to purchase up to an additional $2,000,000 principal amount of January 2004 Debentures commencing in six months, in a private placement for aggregate net proceeds of $3,695,000. The January 2004 Debentures mature on January 31, 2006 and bear interest at 6% per annum, payable quarterly in cash or, subject to satisfaction of certain conditions, common stock. Any shares of common stock and exercised allissued to the investors as payment of interest shall be valued at 95% of the 743,288 warrants, which produced $1,248,724average closing price of the common stock during the five consecutive business days ending on the third business day immediately preceding the applicable interest payment date. Commencing six months after issuance, we are required to start repaying the then outstanding principal amount under the January 2004 Debentures in additional operating funds for the Company. The debenture holders have expressed interestmonthly installments amortized over 18 months in providing additional financing on similar terms with some modificationscash or, at our option, in shares of common stock. Any shares of common stock issued to the original debenture. The Company is considering this offer and, if accepted, would use someinvestors as installment payments shall be valued at 95% of the average closing price of the common stock during the 10-day trading period commencing on and including the eleventh trading day immediately preceding the date that the installment is due. The January 2004 Debentures are convertible at the option of the investors at any time through January 31, 2006 into shares of our common stock. The conversion price under the shares included in the increased authorization. Other than this offer, the Company has no specific plans with regardJanuary 2004 Debentures is fixed at $2.53 per share, subject to its useadjustment for anti-dilution protection for issuance of the authorized but unissued/unreserved shares; however, it anticipates that it will (i) attempt to raise capital through the sale of its common stock or securities convertible or exchangeable into common stock at a price less than the conversion price then in effect. In addition, in the event that we do not pay the redemption price at maturity, the Debenture holders, at their option, may convert the balance due at the lower of (a) the conversion price then in effect and (b) 95% of the lowest closing sale price of our common stock during the three trading days ending on and including the conversion date. There are two classes of July 2009 warrants received by the Investors: Class A and Class B. The Class A warrants are to acquire any time from July 26, 2004 through July 26, 2009 an aggregate of up to 395,257 shares of common stock at a price of $3.29 per share. The Class B warrants are to acquire any time from July 26, 2004 through July 26, 2009 an aggregate of up to 395,257 shares of common stock at a price of $5.06 per share. On January 27, 2005, the exercise price of these July 2009 Class A and Class B Warrants will reset to the lesser of their respective exercise price then in effect or a price equal to the average of the daily price of the common stock between January 27, 2004 and January 26, 2005 (but in no event less than $2.58 per share with regard to the Class A warrants and $3.54 per share with regard to the Class B warrants). The exercise price (and the reset price) under the July 2009 Warrants also is subject to similar adjustments for anti-dilution protection. The above mentioned AIR grant the investors the right to acquire up to an additional $2,000,000 principal amount of January 2004 Debentures from us. These Debentures are identical to the January 2004 Debentures except that the conversion price is $2.58. The AIR are exercisable commencing on July 26, 2004 (the "Trigger" date) for Common Stock: and/a period of 90 days from the Trigger Date or 90 days from the date which the registration statement registering the shares issuable upon the conversion of the January 2004 Debentures to be issued pursuant to the AIR is declared effective, whichever is longer. Pursuant to the terms and conditions of the July Debentures, October Debentures and January 2004 Debentures (collectively, the "Debentures"), we have pledged all of our assets, other than our intellectual property, as collateral, and we are subject to comply with certain financial and negative covenants. In addition, we have paid $1,300,000 into the Debenture cash collateral account as required by the terms of the Debentures. The cash collateral account provides additional security for repayment of the Debentures in the event of default. We entered into Registration Rights Agreements with the investors in connection with the issuance of (i) the Debentures (including any Debentures issued pursuant to the AIR); (ii) acquire additional assets.the July 2008, October 2008 and January 2009 Warrants (collectively, the "Warrants"); and (iii) the shares issued in January 2004. Pursuant to the Registration Rights Agreements we have registered on behalf of the investors the shares issued to them in January 2004 and 135% of the shares issuable upon conversion of the Debentures (including any Debentures issued pursuant to the AIR) and upon exercise of the Warrants. If , subject to certain exceptions, sales of all shares so registered cannot be made pursuant to the registration statements, then we will be required to pay to the investors their pro rata share of $3,635 for each day the above condition exists. By agreement with Cardinal Securities, LLC, for general financial advisory services and in conjunction with the private debenture placements in July and October 2003 and in January 2004, we paid Cardinal Securities, LLC an investment banking fee equal to 7% of the investments made by the two Debenture holders and issued to Cardinal the following common stock purchase warrants: (i) 112,500 exercisable at $2.57 per share; (ii) 87,500 exercisable at $2.42 per share; and (iii) 100,000 exercisable at $3.04 per share. The Board$2.57 warrants expire on July 10, 2008, the $2.42 warrants expire on October 30, 2008 and the $3.04 warrants expire on January 5, 2009. By agreement with Cardinal, we have registered 300,000 of Directors has no specific plans, understandings, agreements or commitmentsthe shares issuable upon exercise of these warrants for public sale and agreed to issue additional common shares for capital raising transactions or acquisitions. Failure to obtain stockholdersregister the balance. We are seeking approval of this proposal will not impact the Company's existing agreements to issue common shares. The Board believes that the Company will be adversely impaired of this proposal is not approved. Recommendation and Required Vote The affirmative vote of at least a majorityissuance of the issued and outstanding shares asupon exercise of these warrants too. As of the record date, the investors had converted $11,902,610 of debt from the March, July and October Debentures into 7,073,234 shares of our common stock. The March Debentures have been fully converted. The remaining principal balance on the Debentures is necessaryconvertible into shares of our stock at the option of the investors at any time, through their respective maturity dates. We have used and continue to use the net proceeds from these private offerings for approvaloperating purposes. Effects of Proposal No. 3. Under Delaware law,issuance of the shares A significant number of shares will be issuable upon conversion of the Debentures and exercise of the Warrants. To the extent that a significant number of these shares are issued, there are no rightswill be a substantial pro rata dilution to our current stockholders. In addition, because these shares have been registered for public sale, such sales, or the anticipation of appraisal or dissenter's rights,the possibility of such sales, represents an overhang on the market and could depress the market price of our common stock. However, if issuance of the these shares is not approved by stockholders, we will be unable to issue shares upon exercise of approximately 2,707,751 warrants and we will be unable to issue shares upon conversion of the Debentures issuable upon exercise of the AIR. Depending upon the amount and timing of conversion of the outstanding Debentures, we also may be required to pay interest in cash rather than shares. Pursuant to the terms of the Warrants, if stockholders do not approve this resolutions, any time the Warrant holder presents a notice of exercise, we would be required to pay within two business days an amount in cash equal to the product of (X) the number of shares of common stock which arisecould not be issued multiplied by (Y) the excess of (1) the average of the closing sale prices of the common stock on each of the five trading days ending on the third trading day immediately preceding the date that the Warrants become unexercisable as a result of the stockholders failure to approve this resolution over (2) the warrant exercise price then in effect. Pursuant to the terms of the Debentures issuable upon exercise of the AIR, if stockholders do not approve this resolutions, any time the Debenture holder presents a votenotice of conversion, we would be required to amendpay within two business days an amount in cash equal to the Certificatenumber of Incorporation.shares of common stock which could not be issued multiplied by (Y) the average of the weighted average price of the common stock on each of the five trading days ending on the third trading day immediately preceding the date of delivery of such conversion notice. THE BOARD OF DIRECTORS DEEMS PROPOSAL NO. 3 TO BE IN THE BEST INTERESTS OF HEMISPHERX AND ITS STOCKHOLDERS AND RECOMMENDS A VOTE "FOR" APPROVAL THEREOF. PROPOSAL NO. 4 APPROVAL OF THE HEMISPHERx 2004 EQUITY INCENTIVE PLAN The Company is submitting the Hemispherx 2004 Equity Incentive Plan (the "Equity Incentive Plan") to the stockholders for approval at the annual meeting. The Equity Incentive Plan is intended to attract and retain individuals of experience and ability, to provide incentive to employees, consultants, and non-employee directors of the Company, to encourage employee and director proprietary interests in the Company, and to encourage employees to remain in the employ of the Company. The Equity Incentive Plan is conditioned upon the stockholders' approval. The purposes of obtaining stockholder approval include qualifying the Equity Incentive Plan under the Internal Revenue Code (the "Code") for the granting of incentive stock options; meeting the requirements for tax-deductibility of certain compensation items under Section 162(m) of the Code; and meeting the requirements of AMEX applicable to the Equity Incentive Plan. The following general description of certain features of the Equity Incentive Plan is qualified in its entirety by reference to the Equity Incentive Plan, which is attached as Appendix A. Capitalized terms not otherwise defined herein have the meanings ascribed to them in the Equity Incentive Plan. The Board of Directors adopted the Equity Incentive Plan effective May 1, 2004, subject to the approval of the Company's stockholders. The Equity Incentive Plan authorizes the grant of non-qualified and incentive stock options, stock appreciation rights, restricted stock and other stock awards. A maximum of 8,000,000 shares of common stock is reserved for potential issuance pursuant to awards under the Equity Incentive Plan. Unless sooner terminated, the Equity Incentive Plan will continue in effect for a period of 10 years from its effective date. The Equity Incentive Plan is administered by the Board of Directors. The Equity Incentive Plan provides for awards to be made to such officers, other key employees, non-employee directors, consultants and advisors of the Company and its subsidiaries as the Board may select. No awards have been granted under the Equity Incentive Plan. Stock options awarded under the Equity Incentive Plan may be exercisable at such times (not later than 10 years after the date of grant) and at such exercise prices (not less than fair market value at the date of grant) as the Board may determine. The Board may provide for options to become immediately exercisable upon a "change in control," which is defined in the Equity Incentive Plan to occur upon any of the following events: (a) the acquisition by any person or group, as beneficial owner, of 20% or more of the outstanding shares or the voting power of the outstanding securities of the Company; (b) either a majority of the directors of Company at the annual stockholders meeting has been nominated other than by or at the direction of the incumbent directors of the Board, or the incumbent directors cease to constitute a majority of the Company's Board; (c) the Company's stockholders approve a merger or other business combination pursuant to which the outstanding common stock of the Company no longer represents more than 50% of the combined entity after the transaction; (d) the Company's shareholders approve a plan of complete liquidation or an agreement for the sale or disposition of all or substantially all of the Company's assets; or (e) any other event or circumstance determined by the Company's Board to affect control of the Company and designated by resolution of the Board as a change of control. The exercise price of an option may be paid with cash, common stock, or such other consideration as the Board may specify. No options may be granted under the Equity Incentive Plan after the tenth anniversary of its effective date. Unless the Board determines otherwise, options will be transferable only by will or the laws of descent and distribution. Stock appreciation rights awarded under the Equity Incentive Plan may be granted as related rights, either in connection with and at the same time as an option is granted, or by amendment of an outstanding non-qualified option. A related stock appreciation right may be granted with respect to all or some of the shares covered by the related option. Related stock appreciation rights generally become exercisable at the same times as the related options become exercisable, but may be limited so as to become exercisable only upon certain events, such as a change in control. Upon exercise of a related right, the grantee would receive, in lieu of purchasing stock, either stock or cash equal to the difference between the fair market value on the date of exercise of the underlying shares of common stock subject to the related option and the exercise price of the option. Stock appreciation rights may also be granted independently of any option, to become exercisable at such times as the Board may determine. Upon exercise of such a right, the grantee would receive either stock or cash equal to the difference between the fair market value on the date of exercise of the shares of common stock subject to the right and the fair market value of the shares on the date of grant of the right. Restricted stock awarded under the Equity Incentive Plan may be granted on such terms and conditions as the Board may determine, including provisions that govern the lapse of restrictions and voting dividend, distribution and other shareholder rights with respect to the restricted stock. If a grantee of restricted stock terminates service with the Company for any reason, the grantee will forfeit to the Company any restricted stock on which the restrictions have not lapsed or been removed on or before the date of termination of service. Other stock awards under the Equity Incentive Plan may provide for common stock to be issued to grantees in exchange for consideration specified by the Board that is either the grantee's cash or other direct payment to the Company or the grantee's past services rendered to the Company or a subsidiary on or before issuance. The following is a brief summary of certain of the U.S. federal income tax consequences of certain transactions under the Equity Incentive Plan based on federal income tax laws in effect on January 1, 2004. This summary applies to the Equity Incentive Plan as normally operated and is not intended to provide or supplement tax advice to eligible employees. The summary contains general statements based on current U.S. federal income tax statutes, regulations and currently available interpretations thereof. This summary is not intended to be exhaustive and does not describe state, local or foreign tax consequences or the effect, if any, of gift, estate and inheritance taxes. Grants of options or stock appreciation rights are not taxable income to the grantees or deductible for tax purposes by the Company at the time of the grant. In the case of non-qualified stock options, a grantee will be deemed to receive ordinary income upon exercise of the stock option, and the Company will be entitled to a corresponding deduction, in an amount equal to the amount by which the fair market value of the common stock purchased on the date of exercise exceeds the exercise price. The exercise of an incentive stock option will not be taxable to the grantee or deductible by the Company, but the amount of any income deemed to be received by a grantee due to premature disposition of common stock acquired upon the exercise of an incentive stock option will be a deductible expense of the Company for tax purposes. In the case of stock appreciation rights, a grantee will be deemed to receive ordinary income upon exercise of the right, and the Company will be entitled to a corresponding deduction, in an amount equal to the cash or fair market value of shares payable to the grantee. Grantees of restricted stock awards generally will recognize ordinary income in an amount equal to the fair market value of the shares of common stock granted to them at the time that the restrictions on the shares lapse and the shares become transferable. At that time, the Company will be entitled to a corresponding deduction equal to the amounts recognized as income by the grantees in the year in which the amounts are included in the grantees' income. Grantees of stock issued pursuant to other stock awards will generally receive ordinary income, and the Company will be entitled to a corresponding deduction, in an amount equal to the amount by which the fair market value of the common stock on the date of issuance exceeds the grantee's cash or other payment to the Company, if any. Section 162(m) of the Code generally disallows a publicly held corporation's tax deduction for certain compensation in excess of $1 million per year paid to each of the five most highly compensated executive officers, exclusive of compensation that is "performance-based." The Company has designed the Equity Incentive Plan in a manner that is intended to qualify the options and any stock appreciation rights granted under the Equity Incentive Plan as performance-based compensation that will not be subject to the deduction limitation of Section 162(m). Any grant of restricted stock or other stock award could (but is not required to) be designed to avoid any such deduction limitation. The Board has the general power to amend the Equity Incentive Plan in any respect. However, if the Equity Incentive Plan is approved by the stockholders at the annual meeting, the Board may not, without further approval of the Company's stockholders, amend the Plan so as to increase the aggregate number of shares of common stock that may be issued under the Equity Incentive Plan, modify the requirements as to eligibility to receive awards, or to increase materially the benefits accruing to participants. In addition, the Board is permitted to modify, extend or renew outstanding stock options or stock appreciation rights, and to authorize the granting of new options or stock appreciation rights in substitution for existing options and rights. However, existing options or rights may not be repriced, directly or indirectly, so as to provide for modified or new options or rights with an exercise price lower than the exercise price provided for the outstanding stock options and stock appreciation rights. The Board is also authorized to accelerate the lapse of restrictions on restricted stock awards or to remove any or all restrictions at any time. THE BOARD OF DIRECTORS DEEMS PROPOSAL NO. 4 TO BE IN THE BEST INTERESTS OF HEMISPHERx AND ITS STOCKHOLDERS AND RECOMMENDS A VOTE FOR THE APPROVAL OF THE HEMISPHERx 2004 EQUITY INCENTIVE PLAN GENERAL Unless contrary instructions are indicated on the proxy, all shares of common stock represented by valid proxies received pursuant to this solicitation (and not revoked before they are voted) will be voted FOR the election of all directors nominated and FOR ProposalProposals No. 2, 3 and 3.4. The Board of Directors knows of no business other than that set forth above to be transacted at the meeting, but if other matters requiring a vote of the stockholders arise, the persons designated as proxies will vote the shares of common stock represented by the proxies in accordance with their judgment on such matters. If a stockholder specifies a different choice on the proxy, his or her shares of common stock will be voted in accordance with the specification so made. IT IS IMPORTANT THAT PROXIES BE RETURNED PROMPTLY. WE URGE YOU TO FILL IN, SIGN AND RETURN THE ACCOMPANYING FORM OF PROXY IN THE PREPAID ENVELOPE PROVIDED, NO MATTER HOW LARGE OR SMALL YOUR HOLDINGS MAY BE. By Order of the Board of Directors, Ransom W. Etheridge, Secretary Philadelphia, Pennsylvania July ____, 2003 APPENDIX "A" CERTIFICATE OF AMENDMENT OF THE CERTIFICATE OF INCORPORATION OF HEMISPHERX BIOPHARMA, INC. Under Section 242 of the Corporation Law of the State of Delaware William A. Carter, the President of HEMISPHERX BIOPHARMA, INC. (the "Company")May , a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware, DOES HEREBY CERTIFY: FIRST: That the Board of Directors of said corporation, by written consent filed with the minutes of the Board, adopted the following resolutions proposing and declaring advisable the following amendment to the Certificate of Incorporation of said corporation: "Article `FOURTH' of the Certificate of Incorporation, which sets forth the capitalization of the Company, is amended and, as amended, reads as follows: `FOURTH. The total number of shares of all classes of capital stock which the Corporation shall have authority to issue is 105,000,000 of which 100,000,000 shares shall be Commons Stock of the par value of $0.001 and 5,000,000 shares shall be Preferred Stock of the par value of $0.01, with such designations, rights and preferences as may be determined from time to time by the Board of Directors.'" SECOND: That the aforesaid amendment was duly adopted in accordance with the applicable provisions of section 242 of the General Corporation Law of the State of Delaware. IN WITNESS WHEREOF, the undersigned, being the President hereinbefore named, has executed, signed and acknowledged this amendment to the Certificate of Incorporation this day of ________, A.D. 2003. 1462: William A. Carter, President PRELIMINARY COPY OF PROXY CARD HEMISPHERX BIOPHARMA, INC. ANNUAL MEETING OF STOCKHOLDERS SEPTEMBER 10, 2003 THIS PROXY IS SOLICTED ON BEHALF OF THE BOARD OF DIRECTORS The undersigned hereby appoints William A. Carter and Ransom W. Etheridge and each of them, with full power of substitution, as proxies to represent the undersigned at the Annual Meeting of Stockholders to be held at the Embassy Suites, 1776 Benjamin Franklin Parkway, Philadelphia, Pennsylvania 19103, on Wednesday, September 10, 2003, at 10:00 a.m. local time and at any adjournment thereof, and to vote all of the shares of common stock of Hemispherx Biopharma, Inc. the undersigned would be entitled to vote if personally present, upon the following matters: Please mark box in blue or black ink. 1. Proposal No.1-Election of Directors. Nominees: William A. Carter, Richard C. Piani, Ransom W. Etheridge, William M. Mitchell, and Iraj-Eqhbal Kiani. / /For all nominees (except as marked // Authority Withheld as to all to the contrary below) Nominees (INSTRUCTION: TO WITHHOLD AUTHORITY TO VOTE FOR ANY INIVDUAL NOMINEE, STRIKE A LINE THROUGH THE NOMINEE'S NAME) William A. Carter Richard C. Piani Ransom W. Etheridge William M. Mitchell Iraj-Eqhbal Kiani 2. Proposal No. 2-Ratification of the selection of BDO Seidman, LLP, as independent auditors of Hemispherx Biopharma, Inc. for the year ending December 31, 2003. For // Against // Abstain // 3. In their discretion, the proxies are authorized to vote upon such other business as may properly come before the meeting. 4. Proposal No. 3 - Amend the Company's Certificate of Incorporation to increase the authorized shares of common stock from 50,000,000 to 100,000,000. For // Against // Abstain // THE SHARES REPRESENTED BY THIS PROXY WILL BE VOTED AS DIRECTED. THE BOARD RECOMMENDS A VOTE "FOR" ITEMS NOS. 1, 2 AND 3. IF NO CONTRARY INSTRUCTION IS GIVEN, THE SHARES WILL BE VOTED FOR THE ELECTION OF WILLIAM A. CARTER, RICHARD C. PIANI, RANSOM W. ETHERIDGE, WILLIAM A. MITCHELL AND IRAJ-EQHBAL KIANI AS DIRECTORS, FOR PROPOSALS NO. 2 AND 3 AND IN THE DISCRETION OF THE PROXIES ON ALL OTHER MATTERS PROPERLY BROUGHT BEFORE THE ANNUAL MEETING. Please date, sign as name appears at left, and return promptly. If the stock is registered in the name of two or more persons, each should sign. When signing as Corporate Officer, Partner, Executor, Administrator, Trustee, or Guardian, please give full title. Please note any change in your address alongside the address as it appears in the Proxy. Dated: ----------------------------- Signature ----------------------------- ----------------------------- (Print Name) SIGN, DATE AND RETURN PROXY CARD PROMPTLY USING THE ENCLOSED ENVELOPE2004